Traumatic brain injury. Concussion
Conditions
Interventions
Intervention 1: Intervention group: Indomethacin in the amount of 25 mg for 5 days will be administered intravenously in an initial loading dose of 0.8 mg/kg in 100 cc of normal saline solution over 1
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: Registration of informed consent of the first degree patient to participate in the study Age 16 to 70 years Severe traumatic brain injury with closed or penetrating mechanism High resistant ICP 8 =GCS
Exclusion criteria
Exclusion criteria: Pregnancy Brain death Coagulation disorders History of gastrointestinal bleeding or active bleeding History of peptic ulcer Acute kidney injury History of allergies to nonsteroidal anti-inflammatory drugs Clinical signs and symptoms of renal failure or its history Hyperkalemia Liver failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severe traumatic brain injury. Timepoint: It will be measured again one month and 6 months after administration. Method of measurement: Visual Analogue Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of disability or dependence in daily activities. Timepoint: It will be measured again one month and 6 months after administration. Method of measurement: Visual Analogue Scale.;Severe traumatic brain injury. Timepoint: It will be measured again one month and 6 months after administration. Method of measurement: Visual Analogue Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeed Ehteshami
Mazandaran University of Medical Sciences
Outcome results
None listed