Deep muscular blockage with Rocoronium and abdominal compliance.
Conditions
Interventions
Intervention 1: The first intervention group: Deep muscular blockage (TOF=0 or PTC=0-4) with Rocuronium accompanied by inhalation anesthesia. Intervention 2: The second intervention group: Deep muscul
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients undergoing laparoscopic cholecystectomy Conscious consent for study No allergic reaction to all drugs used BMI (Body Mass Index) <35 Lack of hypertension, respiratory disease, history of aspiration, liver and kidney diseases, neuromuscular diseases, dwarf and patients with active infection
Exclusion criteria
Exclusion criteria: Dissatisfaction BMI>35 Patients whose operation is finally opened Allergic reaction to all drugs used Hypertension, respiratory disease, history of aspiration, liver and kidney diseases, neuromuscular diseases, dwarf and patients with active infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of deep muscular blockage on intra-abdominal pressure in laparoscopic cholecystectomy after inhaled anesthesia in laparascopic cholecystectomy. Timepoint: Muscular blockage is monitored to maintain TOF = 1-3, PTC = 4-8. To maintain the blockage, Rocuronium infusion is started at a rate of 20 mg per hour and titrated for the desired relaxation. Intra-abdominal pressure is measured at this rate of relaxation. In groups with deep relaxation, the rate of Rocronium infusion will be increased and titrated to achieve TOF = 0 and PTC = 0-4. Changes in abdominal pressure are measured in both anesthesic methods. Method of measurement: Intra-abdominal pressure will be measured with laparoscope and the abdominal compliance by measuring the length of the xiphoid to the pubis.;The effect of deep muscular blockage with Recuronium on intra-abdominal pressure in laparoscopic cholecystectomy with total intravenous anesthesia. Timepoint: Before and after deep muscular blockage. Method of measurement: The TOF and POC values will be measured before and after deep muscular blockage. | — |
Secondary
| Measure | Time frame |
|---|---|
| The effect of deep muscular blockage with Recuronium on the quality of operating conditions in laparoscopic cholecystectomy anesthesized with isoflurane. Timepoint: Before and after deep muscular blockage. Method of measurement: 1: Extremely poor conditions: the surgeon is unable to work because of coughing or because of the inability to obtain a visible laparoscopic field because of inadequate muscle relaxation. Additional neuromuscular blocking agents must be given.2: Poor conditions: there is a visible laparoscopic field, but the surgeon is severely hampered by inadequate muscle relaxation with continuous muscle contractions, movements, or both with the hazard of tissue damage. Additional neuromuscular blocking agents must be given.3: Acceptable conditions: there is a wide visible laparoscopic field, but muscle contractions, movements, or both occur regularly, causing some interference with the surgeon’s work. There is a need for additional neuromuscular blocking agents to prevent deterioration.4: Good conditions: there is a wide laparoscopic working field with sporadic muscle contractions, movements, or both. There is no immediate need for additional neuromuscular blocking agents unless there is a fear of deterioration.5: Optimal conditions: there is a wide visible laparoscopic working field without any movement or contractions.;The effect of deep muscular blockage with Rocronium on the quality of operating conditions in laparoscopic cholecystectomy with total intra venous anesthesia. Timepoint: Before and after deep muscular blockage. Method of measurement: 1: Extremely poor conditions: the surgeon is unable to work because of coughing or because of the inability to obtain a visible laparoscopic field because of inadequate muscle relaxation. Additional neuromuscular blocking agents must be given.2: Poor conditions: there is a visible laparoscopic field, but the surgeon is severely hampered by inadequate muscle relaxation with continuous muscle contractions, mov | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamzeh Hosseinzadeh
Tabriz University of Medical Sciences
Outcome results
None listed