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Evaluation of the effect of Ranolazine on patients with slow flow coronary arteries

Evaluation of the effect of oral Ranolazine on the clinical symptoms of patients with slow flow coronary arteries

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220516054874N6
Enrollment
48
Registered
2022-09-24
Start date
2022-10-07
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary slow flow syndrome. Other forms of angina pectoris

Interventions

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to No maximum

Inclusion criteria

Inclusion criteria: Consent to admission to the study Age more than 30 years old Patients who have less than 50% stenosis in each of the 3 main coronary arteries in their coronary angiography and have delayed filling in at least one of the coronary arteries and have slow coronary flow in a corrected TIMI frame count of more than 27 frames per second

Exclusion criteria

Exclusion criteria: Intolerance or allergy to Ranolazine History of known congenital heart disease History of any cardiovascular diseases other than mild coronary atherosclerosis

Design outcomes

Primary

MeasureTime frame
Changes in the score of quality of life according to the EuroQol-VAS scale (0-100; 100 is the best quality of life and 0 is the worst quality of life). Timepoint: Before intervention and 1, and 2 months after beginning the intervention. Method of measurement: According to the EuroQol-VAS scale (0-100; 100 is the best quality of life and 0 is the worst quality of life).

Secondary

MeasureTime frame
Frequent pain during the day. Timepoint: Before intervention and 1, and 2 months after beginning the intervention. Method of measurement: Frequent pain during the day.;Duration of pain in minutes. Timepoint: Before intervention and 1, and 2 months after beginning the intervention. Method of measurement: Duration of pain in minutes.;Pain intensity based on activity according to Canadian Cardiovascular Society (CCS) Grading of Angina Pectoris. Timepoint: Before intervention and 1, and 2 months after beginning the intervention. Method of measurement: According to Canadian Cardiovascular Society (CCS) Grading of Angina Pectoris.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Vafa Baradaran Rahimi

Mashhad University of Medical Sciences

baradaranrv@mums.ac.ir0095 5138012739

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026