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The effect of administration of midazolam and ketorolac in comparison with administration of morphine and ketorolac on pain relief in patients with renal colic

Investigating the effect of prescribing midazolam and ketorolac in comparison with prescribing morphine and ketorolac on the pain relief of renal colic patients referred to the emergency department of Khatam al-Anbia in Zahedan in 2025

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220516054869N5
Enrollment
200
Registered
2024-11-10
Start date
2025-03-20
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain management of renal colic patients. Acute pain, not elsewhere classified

Interventions

Intervention 1: Intervention group: In the first group, 30 mg of intravenous ketorolac will be administered within one minute and 5 mg of intravenous morphine (in a volume of 5 cc) will be prescribed

Sponsors

Zahedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 75 Years

Inclusion criteria

Inclusion criteria: Men or women will be 15 to 75 years old, who will be diagnosed with acute renal colic by radiography or ultrasound (based on the opinion of the emergency medicine doctor) They will get a score of 4 or higher on the visual analog scale (VAS). Hemodynamically stable (based on initial triage) Consent of patients or patients' companions to enter the study

Exclusion criteria

Exclusion criteria: Allergy to morphine, ketorolac or midazolam Renal dysfunction (according to GFR and BUN, Cr) Having one kidney or a history of kidney transplant Intravenous painkiller was consumed in 4 hours Paralytic ileus Heart failure due to chronic lung disease Convulsive disorders, acute respiratory failure Acute angle-closure glaucoma Severe low blood pressure or shock History of allergy to other NSAIDS Hemorrhagic disease Having coagulation disorders (or taking warfarin) Having vascular and cerebral lesions Having underlying diseases such as mental disorders, having fibromyalgia, cardiovascular disease, digestive diseases Drug addiction Pregnancy and breastfeeding

Design outcomes

Primary

MeasureTime frame
Renal colic pain. Timepoint: At the beginning of the study and at 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Visual analog scale.;Level of sedation. Timepoint: At the beginning of the study and at 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Ramsay criterion.;Oxygen saturation percentage. Timepoint: At the beginning of the study and at 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Pulse oximetry device.;Respiratory rate. Timepoint: At the beginning of the study and at 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Counting by the nurse.

Secondary

MeasureTime frame
Headache. Timepoint: At 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Having or not having a side effect after the intervention.;Hypotension or hypertension. Timepoint: At 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Pressure gauge device.;Dizziness. Timepoint: At 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Having or not having a side effect after the intervention.;Sleepiness. Timepoint: At 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Having or not having a side effect after the intervention.;Decreased tendon reflex. Timepoint: At 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Having or not having a side effect after the intervention.;Arrhythmia (tachycardia, bradycardia). Timepoint: At 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Observation in monitoring.;Skin lesions. Timepoint: At 20, 40, 60 and 90 minutes after the intervention. Method of measurement: Observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Abdolrazaghnejad

Zahedan University of Medical Sciences

ali.abdorazzagh@gmail.com+98 54 3323 2890

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026