Determining the effects of mouthwash from areal parts Alhagi sp. aerial parts extract on paraquat-induced oral ulcers in poisoned patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220515054856N1

Enrollment

Registered

2022-07-23

Start date

2022-06-22

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paraquat herbicide poisoning.

Interventions

Intervention 1: The first intervention group: Triamcinolone paste (made in Iran, manufacturer: Emad Darman Pars Chemical formula: C21H27FO6) which is given to the patient 3 times a day (every 8 hours)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Definitive use of paraquat herbicide with toxic dose (based on history, clinical examination, endoscopic findings) Patient consent to participate in the study

Exclusion criteria

Exclusion criteria: Poisoning with other herbicides other than paraquat (based on history, clinical examination, endoscopic findings) Non-toxic dose of paraquat (endoscopy and normal tests) Patient dissatisfaction to participate in the study Patients do not cooperate to take medicine due to mouth ulcers

Design outcomes

Primary

Measure	Time frame
The rate of change (decrease or increase) in the size of oral lesions. Timepoint: 3, 7 and 30 days after patient visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Evaluation of difficulty in eating due to its consistency. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Check the Speech Problem. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Check for discomfort when opening and moving the mouth. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Check for swallowing problems. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Check the number of areas involved in the oral cavity. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Measuring pain intensity. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Questionnaire,The Numeric Pain Rating Scale (NPRS).;Recovery time. Timepoint: From the beginning until the recovery every 4 days. Method of measurement: follow up(Examining the patient and asking the patient).	—

Measure

Time frame

The rate of change (decrease or increase) in the size of oral lesions. Timepoint: 3, 7 and 30 days after patient visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Evaluation of difficulty in eating due to its consistency. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Check the Speech Problem. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Check for discomfort when opening and moving the mouth. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Check for swallowing problems. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Check the number of areas involved in the oral cavity. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Pemphigus Oral Lesions Intensity Score (POLIS) Questionnaire.;Measuring pain intensity. Timepoint: At the beginning of the study (before the intervention) and 3, 7 and 30 days after the patient's visit and discharge time. Method of measurement: Questionnaire,The Numeric Pain Rating Scale (NPRS).;Recovery time. Timepoint: From the beginning until the recovery every 4 days. Method of measurement: follow up(Examining the patient and asking the patient).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKerman University of Medical Sciences

Kerman University of Medical Sciences

nairimajdfaranak@gmail.com+98 34 3132 5700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026