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Effect of Ashwagandha in treatment of Alzheimer

Evaluating the efficacy of herbal preparation Ashwagandha (Withania somnifera (L.) Dunal) on disease severity in patients with mild to moderate Alzheimer's disease: A triple-blind clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220514054845N1
Enrollment
100
Registered
2024-08-19
Start date
2024-06-19
Completion date
Unknown
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's disease. Alzheimer disease, unspecified

Interventions

Intervention 1: Intervention group: The intervention group, which includes 50 patients with mild to moderate Alzheimers disease between the ages of 50 and 85, will take two 250 mg capsules of hydroalc

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 85 Years

Inclusion criteria

Inclusion criteria: Having informed consent for study participation Having a CDR score less than or equal to 2 Having an ADAS-COG score higher than or equal to 12 Ability to participate in the study

Exclusion criteria

Exclusion criteria: Inability to participate in the study Inability to continue treatment Presence of heart disease Substance abuse and alcohol addiction Taking anticoagulant drugs

Design outcomes

Primary

MeasureTime frame
Alzheimer's severity score in CDR and ADAS-COG questionnaire. Timepoint: At the beginning of the study (before the start of the intervention), at the end of every 4 weeks to three months after the start of taking the drug and placebo. Method of measurement: CDR (Clinical Dementia Rating Scale-Sum of Boxes) and ADAS-Cog (Alzheimer's Disease Assessment Scale-Cognitive Subscale) questionnaires.

Secondary

MeasureTime frame
Side effects. Timepoint: End of the third month. Method of measurement: questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdieh. Mobayyen

Kerman University of Medical Sciences

m.mobayyen@kmu.ac.ir0098 34 31336163, 0098 34 31336161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026