Comparison of the effectiveness of tDCS, ACT and their combined effect on negative emotion, impulsiveness, perceived stress, cortisol? and estrogen levels in patients with migraine

Comparison of the effectiveness of Transcranial Direct Current Stimulation (tDCS), Acceptance and Commitment Therapy (ACT) and their combined effect on negative emotion, impulsiveness, perceived stress, cortisol? and estrogen levels in patients with migraine headache

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220511054824N1

Enrollment

120

Registered

2023-09-11

Start date

2022-04-21

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine headaches.

Interventions

Intervention 1: The first intervention group, Transcranial Direct Current Stimulation (tDCS): The brain regions were localized using the EEG 10/20 system, and the anode and the cathode were located ov

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Taking confirmed diagnosis of migraine, signing the written consent, Proficiency in Persian language, having access to the Internet and the Skype software (for groups taking the ACT course), being between the ages of 20 and 40, having no other effective physical or psychological conditions, and not undergoing drug and other treatments

Exclusion criteria

Exclusion criteria: Receiving another treatment during the intervention, having a history of a serious medical or neurological disorder (for participants who received tDCS), such as multiple sclerosis, brain injury or tumors, Parkinson’s disease, seizures, dementia, brain stroke or any kind of heart disease, Huntington’s chorea, having cardiac pacemaker, having any metal objects in or near the head, and implanted medication pumps which would increase the risk of tDCS

Design outcomes

Primary

Measure	Time frame
Negative emotion, impulsiveness, perceived stress, blood cortisol and estrogen levels. Timepoint: Before the start of the intervention, after the end of the intervention and three months after the end of the intervention. Method of measurement: Positive and negative affect scale (PANAS), Barratt impulsiveness scale (BIS), Perceived stress scale (PSS), Blood test to measure cortisol and estrogen levels.	—

Measure

Time frame

Negative emotion, impulsiveness, perceived stress, blood cortisol and estrogen levels. Timepoint: Before the start of the intervention, after the end of the intervention and three months after the end of the intervention. Method of measurement: Positive and negative affect scale (PANAS), Barratt impulsiveness scale (BIS), Perceived stress scale (PSS), Blood test to measure cortisol and estrogen levels.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactYasaman Damirchi

Islamic Azad University

yasaman.damirchi@gmail.com+98 26 3425 9571

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026