Comparison of the effect of vitamin D and vitamin C cream and their composition on pregnancy striae in first pregnant women

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220509054799N1

Enrollment

120

Registered

2022-06-06

Start date

2022-05-22

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy striae.

Interventions

Intervention 1: Intervention group: Consumer of vitamin D - Participants receive topical vitamin D 5000 units per 100 grams of uranda base cream (containing alcohol, glycerin, triethanolamine, mono-st

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Primigravid healthy pregnant women The age group of 20-40 years, 18-20 weeks pregnancy Body mass index 18.5-25 Have a minimum literacy

Exclusion criteria

Exclusion criteria: Known systemic or underlying disease (such as gestational diabetes, preeclampsia, adrenal insufficiency, and Cushing's disease) Multiple pregnancies History of pre-striae skin diseases History of allergies to vitamin D and C. Maternal polyhydramnios Diagnosis of macrosomic embryos

Design outcomes

Primary

Measure	Time frame
Striae are skin changes that occur in situations where the skin is under the physical pull of sudden growth during adolescence, pregnancy, or in conditions such as Cushing's syndrome, in which severe hormonal changes occur in the body. In mid-pregnancy, reddish, slightly sunken streaks usually form on the skin of the abdomen and sometimes on the skin above the breasts and thighs. These are called stria gravidarum or stretch marks. These lines lose their pigmentation some time after delivery, turn oyster white, and eventually remain atrophic, slightly wrinkled, and sunken over time. Timepoint: Before, 4, 8, 12 and 16 weeks after the start of the intervention. Method of measurement: In this study, the practical definition is in accordance with the above theoretical definition and the Atwal scale is used to measure this variable. This scale is used to classify women based on the severity of striae. Based on this system, the abdomen, breast, thighs and buttocks are examined for the severity of erythema and the number of stretch marks. The maximum score in each area is 6. The total score is 0-3 without striae or without significant striae, the total score is 4-9 mild striae, the total score is 10-15 moderate striae and the total score is more than 16 is severe striae.	—

Measure

Time frame

Striae are skin changes that occur in situations where the skin is under the physical pull of sudden growth during adolescence, pregnancy, or in conditions such as Cushing's syndrome, in which severe hormonal changes occur in the body. In mid-pregnancy, reddish, slightly sunken streaks usually form on the skin of the abdomen and sometimes on the skin above the breasts and thighs. These are called stria gravidarum or stretch marks. These lines lose their pigmentation some time after delivery, turn oyster white, and eventually remain atrophic, slightly wrinkled, and sunken over time. Timepoint: Before, 4, 8, 12 and 16 weeks after the start of the intervention. Method of measurement: In this study, the practical definition is in accordance with the above theoretical definition and the Atwal scale is used to measure this variable. This scale is used to classify women based on the severity of striae. Based on this system, the abdomen, breast, thighs and buttocks are examined for the severity of erythema and the number of stretch marks. The maximum score in each area is 6. The total score is 0-3 without striae or without significant striae, the total score is 4-9 mild striae, the total score is 10-15 moderate striae and the total score is more than 16 is severe striae.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Masoumeh Kheirkhah

Iran University of Medical Sciences

kheirkhah.m@iums.ac.ir+98 21 4365 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026