Sepsis. Sepsis, unspecified organism
Conditions
Interventions
Intervention 1: Intervention group: The intervention group will receive 90 mg capsules of Nicovid, which is derived from Organosulfur (Daghigh Tajhiz Ario, Tehran, Iran), orally every 6 hours for 7 da
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 18 years Diagnosis of sepsis due to lung infection Not pregnant Not breastfeeding
Exclusion criteria
Exclusion criteria: Having Allicin allergies Having a history of hypotension Having gastrointestinal bleeding Having hypotension Taking warfarin Having immunodeficiency disorders Inability of patient to take oral medication Having hepatic failure Having renal failure Having a history of neuromuscular disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SpO2 level. Timepoint: At the beginning of study and 7 days after intervention. Method of measurement: Pulse Oximeter.;Mortality rate. Timepoint: 7 days after intervention. Method of measurement: Based on acute physiology and chronic health evaluation score (APACHE) II score.;Number of days dependent on ventilator. Timepoint: 7 days after intervention. Method of measurement: The number of days the ventilator is used for the patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| Dependent on vasopressor rate. Timepoint: 7 days after intervention. Method of measurement: The number of times the drug is prescribed to the patient.;Serum level of acute-phase proteins. Timepoint: At the beginning of study and 7 days after intervention. Method of measurement: C-Reactive Protein (CRP) test.;Incidence of respiratory distress. Timepoint: 7 days after intervention. Method of measurement: Based on patient clinical trials. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBenyamin Fazli
Mashhad University of Medical Sciences
Outcome results
None listed