The effectiveness of citrulline supplementation on tolerance and complications of nutritional in patients admitted to the intensive care unit

A clinical trial to compare the effectiveness of citrulline supplementation with placebo on tolerance and complications of nutritional in patients admitted to the intensive care unit

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220508054780N2

Enrollment

Registered

2023-04-26

Start date

2023-05-22

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tolerance and complications of nutritional in patients admitted to the intensive care unit. Other drugs and medicaments

Interventions

Intervention 1: Intervention group: The intervention group will receive 3 mg citrulline supplementation (Daghigh Tajhiz Ario, Tehran, Iran) per day for 14 days. Intervention 2: Control group: The cont

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Aged between 18 and 75 years Non-participation in any other intervention research design

Exclusion criteria

Exclusion criteria: Having citrulline allergies Pregnant women The patient dies in the first 4 days of admission Patient who require of only parenteral nutrition

Design outcomes

Primary

Measure	Time frame
Nutritional status. Timepoint: Before, 2, 7 and 14 days after intervention. Method of measurement: Using by NUTRIC score questionnaire.;Gastrointestinal bleeding. Timepoint: Before, 2, 7 and 14 days after intervention. Method of measurement: Using by the sequential organ failure assessment (SOFA) score.	—

Secondary

Measure	Time frame
Duration of hospital and intensive care unit stay. Timepoint: From the time of admission to the end of the intervention. Method of measurement: Based on the number of days the patient was hospitalized.;Duration of mechanical ventilation. Timepoint: From the time of admission to the end of the intervention. Method of measurement: The rate of using of patient the ventilator.;28-day mortality rate. Timepoint: 28 days after intervention. Method of measurement: Based on days after intervention.	—

Measure

Time frame

Duration of hospital and intensive care unit stay. Timepoint: From the time of admission to the end of the intervention. Method of measurement: Based on the number of days the patient was hospitalized.;Duration of mechanical ventilation. Timepoint: From the time of admission to the end of the intervention. Method of measurement: The rate of using of patient the ventilator.;28-day mortality rate. Timepoint: 28 days after intervention. Method of measurement: Based on days after intervention.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactBenyamin Fazli

Mashhad University of Medical Sciences

fazlib@mums.ac.ir+98 51 3802 2711

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026