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The effect of caffeine on post-appendectomy pain

The effect of caffeine versus placebo on post-appendectomy pain

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220507054763N2
Enrollment
60
Registered
2022-08-08
Start date
2020-03-20
Completion date
Unknown
Last updated
2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-appendectomy pain. Other acute postprocedural pain

Interventions

Intervention 1: Intervention group: 10 min before the end of surgery, one caffeine ampule (30 mg/3 ml) manufactured by Chemi Darou, Iran. Intervention 2: Control group: 10 min before the end of surger

Sponsors

Vice-Chancellery for Research Hormozgan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18-60 years ASA class I & II Candidacy for appendectomy under general anesthesia

Exclusion criteria

Exclusion criteria: Addiction Pregnancy Cardiovascular diseases History of analgesic intake before surgery

Design outcomes

Primary

MeasureTime frame
Post-appendectomy pain. Timepoint: At 1, 2, 8, and 24 hours after surgery. Method of measurement: Visual analogue scale.

Secondary

MeasureTime frame
The amount of analgesics required. Timepoint: At 1, 2, 8, and 24 hours after surgery. Method of measurement: mg Apotel.;Sedation. Timepoint: At 1, 2, 8, and 24 hours after surgery. Method of measurement: Ramsay Sedation Scale (RSS).;Side effects, including hypotension, bradycardia, and respiratory depression. Timepoint: Up to 24 hours after surgery. Method of measurement: Measurement of blood pressure (systolic blood pressure <90 mmHg), heart beat (<60), and respiratory rate (<12).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Abdollahzadeh Baghaei

Bandare-abbas University of Medical Sciences

bagha_ar@yahoo.com+98 76 3334 5009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026