Investigation of the Effectiveness of Schema Therapy and Cognitive-Behavioral Therapy in Patients with Major Depressive Disorder

Investigation of the Effectiveness of Schema Therapy and Cognitive-Behavioral Therapy on Cognitive Flexibility, Negative Automatic Thoughts, Emotional Regulation and Quality of Life in Patients with Major Depressive Disorder

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220504054739N1

Enrollment

Registered

2022-05-14

Start date

2022-05-13

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder. Major depressive disorder, recurrent, moderate

Interventions

Intervention 1: Intervention group: Schema therapy: Ten 90-minute sessions of schema therapy weekly according to the standard protocol of cognitive-behavioral therapy for major depressive disorder. I

Eligibility

Sex/Gender

All

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: A BDI greater score than or equal to 20 Fulfilling all diagnostic criteria of major depressive disorder based on the SCID-5 Providing written informed consent for participation in the study by participants No presence of any other mental disorders No history of mental illness No dependence on alcohol or drugs Do not receive other current psychological treatment

Exclusion criteria

Exclusion criteria: Presence of any suicide thoughts and beliefs More than two absences in treatment sessions

Design outcomes

Primary

Measure	Time frame
Cognitive flexibility: the ability to change cognitive sets to adapt to changing environmental stimuli. Timepoint: One week before the intervention, one week after the last intervention session, one month after the last intervention session. Method of measurement: Questionnaire.;Negative spontaneous thoughts: Thoughts that are not the result of reflection, but automatically and involuntarily invade a person's mind in a particular situation. Timepoint: One week before the intervention, one week after the last intervention session, one month after the last intervention session. Method of measurement: Questionnaire.;Emotional regulation: Behavioral and cognitive strategies for changing the duration or intensity of an emotion experience. Timepoint: One week before the intervention, one week after the last intervention session, one month after the last intervention session. Method of measurement: Questionnaire.;Quality of Life: an individual's perception of their position in life in the context of the culture and value systems. Timepoint: One week before the intervention, one week after the last intervention session, one month after the last intervention session. Method of measurement: Questionnaire.	—

Measure

Time frame

Cognitive flexibility: the ability to change cognitive sets to adapt to changing environmental stimuli. Timepoint: One week before the intervention, one week after the last intervention session, one month after the last intervention session. Method of measurement: Questionnaire.;Negative spontaneous thoughts: Thoughts that are not the result of reflection, but automatically and involuntarily invade a person's mind in a particular situation. Timepoint: One week before the intervention, one week after the last intervention session, one month after the last intervention session. Method of measurement: Questionnaire.;Emotional regulation: Behavioral and cognitive strategies for changing the duration or intensity of an emotion experience. Timepoint: One week before the intervention, one week after the last intervention session, one month after the last intervention session. Method of measurement: Questionnaire.;Quality of Life: an individual's perception of their position in life in the context of the culture and value systems. Timepoint: One week before the intervention, one week after the last intervention session, one month after the last intervention session. Method of measurement: Questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahshid Barouti

Islamic Azad University

mahshidbarooti@gmail.com+98 21 8861 1426

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026