Effect of post-biotic on the number of Streptococcus Mutans in patients undergoing fixed orthodontic treatment.

Comparison of the effect of daily use of mouthwash and toothpaste containing post-biotic on the number of Streptococcus Mutans in the saliva of patients undergoing fixed orthodontic treatment.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220504054736N1

Enrollment

Registered

2022-11-30

Start date

2022-12-22

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries. Dental caries

Interventions

Intervention 1: Intervention group: participants in this group brush their teeth twice a day for 4 weeks, using toothpaste containing post-biotic Bifidobacterium animalis subsp. animalis with a concen

Eligibility

Sex/Gender

All

Age

12 Years to No maximum

Inclusion criteria

Inclusion criteria: Good oral hygiene Good general health Permanent dentition DMF (decay, missing, filling)<5 12 years and older

Exclusion criteria

Exclusion criteria: Use of anti-inflammatory drugs or antibiotics in the last month and during orthodontic treatment Use of products containing Xylitol, Fluoride, Chlorhexidine and probiotics or post-biotics

Design outcomes

Primary

Measure	Time frame
Number of Streptococcus mutans in saliva. Timepoint: before intervention, 4 and 8 weeks after intervention. Method of measurement: Saliva collection and Streptococcus mutans count.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMinoo sadat Alavi

Ahvaz University of Medical Sciences

minooalavi116@gmail.com+98 61 3311 2785

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026