Comparison of the effects of two types of resistance training on hypoxia-inducible factor-1 (HIF-1a), vascular endothelial growth factor, nitric oxide and endothelin-1.

Comparison of the effect of 8 weeks of resistance training with and without blood flow restriction on hypoxia-inducible factor-1 (HIF-1a), vascular endothelial growth factor, nitric oxide and endotelin-1 in men with prehypertension.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220501054712N1

Enrollment

Registered

2023-09-25

Start date

2023-10-07

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary hypertension. Essential (primary) hypertension

Interventions

Intervention 1: Intervention group 1: the high intensity resistance training without blood flow restriction for 8 weeks, 3 sessions per week with an intensity of 75% of one rep-max. Intervention 2: In

Eligibility

Sex/Gender

Male

Age

30 Years to 45 Years

Inclusion criteria

Inclusion criteria: Men with prehypertension Physical and mental health Having no history of regular sport activity during the previous two years Informed personal consent to participate in the study

Exclusion criteria

Exclusion criteria: Having no cardiovascular diseases Having no oncological diseases Having no hormonal diseases Having no acute or chronic diseases Not being addicted to drugs and cigarettes No medication intake

Design outcomes

Primary

Measure	Time frame
Hypoxia-inducible factor-1 (HIF-1a). Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method.;Vascular endothelial growth factor. Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method.;Nitric oxide. Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method.;Endotelin-1. Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method.	—

Measure

Time frame

Hypoxia-inducible factor-1 (HIF-1a). Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method.;Vascular endothelial growth factor. Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method.;Nitric oxide. Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method.;Endotelin-1. Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method.

—

Secondary

Measure	Time frame
Blood pressure. Timepoint: two months. Method of measurement: Measurements will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training using pressure gauge device.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Yari

Islamic Azad University

Aliyari9090@yahoo.com+98 918 343 6046

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026