cerebral ischemic stroke. Acute cerebrovascular insufficiency
Conditions
Interventions
Intervention 1: Intervention group: During the first 24 hours after stroke, Donepezil tablets (Jalinous Company
Iran) will be administered orally at a dose of 5 mg and 10 mg per day. The drug will be administered daily, once a day for six months. The course of treatment will be as follows: during the first 4 we
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with acute ischemic stroke less than 24 hours after the onset of symptoms
Exclusion criteria
Exclusion criteria: More than 24 hours after the onset of symptoms before assigning patients to the control or treatment group transient ischemic attacks Parkinson disease restless legs syndrome heart failure syncope symptomatic bradycardia active asthma or obstructive pulmonary disease recent abdominal surgery recent gastrointestinal bleeding gastrointestinal ulcer renal failure current use of acetylcholinesterase inhibitors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor function following acute ischemic stroke. Timepoint: The first day of admission, three months and six months after the onset of stroke. Method of measurement: Functional Independence Measure and Wisconsin Gait scale.;Cognitive function following acute ischemic stroke. Timepoint: The first day of admission, three months and six months after the onset of stroke. Method of measurement: Mini–mental State Examination test and Alzheimer’s Disease Assessment Scale-Cognitive subscale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: 6-month. Method of measurement: Patients' follow up after 6 months.;Donepezil related side effect. Timepoint: 1-month, 3-month and 6 month. Method of measurement: During one-month, three-month, and six-month follow-ups, patients will be evaluated for side effects of donepezil. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahmoud Yousefifard
Iran University of Medical Sciences
Outcome results
None listed