Recurrent Implantation Failure. Female infertility of uterine origin
Conditions
Interventions
Intervention 1: Intervention group: Intervention group: In the intervention group, PRP patients are performed 48 hours before embryo transfer. For PRP, 8.5 cc of blood is taken from the patient's peri
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age 20 to 40 years 2. History of three failures in implantation following IVF or ICSI or transfer of a total of 10 A quality embryos No immunosuppressive diseases such as lupus, rheumatoid arthritis ....
Exclusion criteria
Exclusion criteria: Use of hormonal methods of contraception (OCP, ampoules, ....) in the last trimester Use of IUD in the laid quarter Hormonal disorders (hypothyroidism, hyperprolactinemia, polycystic ovary syndrome, etc.) Anatomical disorders of the uterus (unicorn, horn, septum, myoma, fibroid, ....) Having Endometriosis Having thrombophilic disorders Active uterine infection in the patient and sexually transmitted infections in his wife and no genital warts Having underlying diseases such as diabetes, hypertension, etc. No immunosuppressive diseases such as lupus, rheumatoid arthritis ....
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chemical pregnancy rate. Timepoint: Two weeks after the intervention. Method of measurement: HCG Beta Blood Test. | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6. Timepoint: Three months after PRP intervention. Method of measurement: Multiplex Immuno assay.;IL-1ß. Timepoint: Three months after PRP intervention. Method of measurement: Multiplex Immuno assay.;IL-5. Timepoint: Three months after PRP intervention. Method of measurement: Multiplex Immuno assay.;IL-10. Timepoint: Three months after PRP intervention. Method of measurement: Multiplex Immuno assay.;IL-12. Timepoint: Three months after PRP intervention. Method of measurement: Multiplex Immuno assay.;IL-15. Timepoint: Three months after PRP intervention. Method of measurement: Multiplex Immuno assay.;IL-17. Timepoint: Three months after PRP intervention. Method of measurement: Multiplex Immuno assay.;IL-18. Timepoint: Three months after PRP intervention. Method of measurement: Multiplex Immuno assay.;TGF-ß. Timepoint: Three months after PRP intervention. Method of measurement: Multiplex Immuno assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBita Pourkaveh
Shahid Beheshti University of Medical Sciences
Outcome results
None listed