"Investigation of the effect of dexmedetomidine infusion versus opioids on pain control, nausea, and vomiting after surgery.

Investigation of the effect of dexmedetomidine infusion versus opioids on pain control, nausea, and vomiting after surgery.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220429054694N2

Enrollment

170

Registered

2024-12-08

Start date

2024-12-25

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Investigating the effect of dexmedetomidine infusion compared to narcotics in controlling postoperative pain. Condition 2: Investigating the effect of dexmedetomidine infusion compared to narcotics in controlling postoperative nausea and vomiting. Upper abdominal pain, unspecified Vomiting following gastrointestinal surgery

Interventions

Intervention 1: Intervention group: Patients are given dexmedetomidine infusion at a dose of 1 µg/kg 10 minutes before the induction, and the induction, like the control group, includes midazolam, pro

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Elective inguinal hernia surger Classified as American Society of Anesthesiologists (ASA) 1 and 2

Exclusion criteria

Exclusion criteria: Allergic reaction to drugs Severe hemodynamic changes during surgery Complex surgery Patients taking drugs affecting QT interval Patients with myopathy and neuropathy. Patients with drug abuse Patients with chronic analgesic use

Design outcomes

Primary

Measure	Time frame
The pain level of the patients during the recovery period up to 24 hours after the operation is checked at 2, 4, 6, 12 and 24 hours. The amount of pain is based on the Visual Analogue Scale, where the lowest amount of pain is scored as zero and the highest amount of pain is scored as 10. The checklists prepared by the evaluator, who is blinded to the study, are performed at 2, 4, 12, and 24 hours. Timepoint: The amount of pain of patients in recovery up to 24 hours after the operation is checked at 2, 4, 6, 12 and 24 hours. Method of measurement: The amount of pain is based on the Visual Analogue Scale, where the lowest amount of pain is scored as 0 and the highest amount of pain is scored as 10.;The rate of nausea and vomiting of patients in recovery up to 24 hours after the operation is checked at 2, 4, 6, 12 and 24 hours. The scoring of nausea and vomiting is 4 points. (score 1 is no nausea and vomiting, score 2 is nausea without vomiting, score 3 is less than two episodes of vomiting, and score 4 is severe vomiting more than 2 episodes). It is done at 2, 4, 12 and 24 hours. Timepoint: The rate of nausea and vomiting of patients in recovery up to 24 hours after the operation is checked at 2, 4, 6, 12 and 24 hours. Method of measurement: The scoring of nausea and vomiting is 4 points. (score 1 is no nausea and vomiting, score 2 is nausea without vomiting, score 3 is less than two episodes of vomiting, and score 4 is severe vomiting more than 2 episodes).	—

Measure

Time frame

The pain level of the patients during the recovery period up to 24 hours after the operation is checked at 2, 4, 6, 12 and 24 hours. The amount of pain is based on the Visual Analogue Scale, where the lowest amount of pain is scored as zero and the highest amount of pain is scored as 10. The checklists prepared by the evaluator, who is blinded to the study, are performed at 2, 4, 12, and 24 hours. Timepoint: The amount of pain of patients in recovery up to 24 hours after the operation is checked at 2, 4, 6, 12 and 24 hours. Method of measurement: The amount of pain is based on the Visual Analogue Scale, where the lowest amount of pain is scored as 0 and the highest amount of pain is scored as 10.;The rate of nausea and vomiting of patients in recovery up to 24 hours after the operation is checked at 2, 4, 6, 12 and 24 hours. The scoring of nausea and vomiting is 4 points. (score 1 is no nausea and vomiting, score 2 is nausea without vomiting, score 3 is less than two episodes of vomiting, and score 4 is severe vomiting more than 2 episodes). It is done at 2, 4, 12 and 24 hours. Timepoint: The rate of nausea and vomiting of patients in recovery up to 24 hours after the operation is checked at 2, 4, 6, 12 and 24 hours. Method of measurement: The scoring of nausea and vomiting is 4 points. (score 1 is no nausea and vomiting, score 2 is nausea without vomiting, score 3 is less than two episodes of vomiting, and score 4 is severe vomiting more than 2 episodes).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Alipour

Mashhad University of Medical Sciences

alipourm@mums.ac.ir+98 51 3858 3878

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026