The effect of oral nutrition supplement consumed as a late evening snack in patients with liver cirrhosis

The effect of oral nutrition supplement consumed as a late evening snack on nutritional status and functional indicators of sarcopenia in patients with liver cirrhosis: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220426054667N5

Enrollment

Registered

2025-09-04

Start date

2025-09-22

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver cirrhosis. Other and unspecified cirrhosis of liver

Interventions

Intervention 1: Intervention group: oral nutrition supplement consumed as a late evening snack. The polymeric powder formula, which is a standard dietary supplement, with a ratio of 55% carbohydrates,

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Having liver cirrhosis diagnosed for at least 6 months Age range from 30 to 60 years Willingness to participate in the study

Exclusion criteria

Exclusion criteria: MELD score greater than 18 or Child-Pugh Class C Active gastrointestinal bleeding Overt hepatic encephalopathy Suffering from heart failure, diabetes, pulmonary diseases, psychological disorders, hepatocellular carcinoma and other cancers Pregnancy, lactation, and menopause

Design outcomes

Primary

Measure	Time frame
Handgrip strength. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Dynamometer.;4-metre Gait Speed Test. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: chronometer.;Five Times Sit to Stand Test. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Chronometer.	—

Secondary

Measure	Time frame
Weight. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Digital scale.;Body Mass Index (BMI). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Weight (Kg)/height(m)2.;Middle Arm Circumference (MAC). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Tape.;Triceps skin fold (TSF). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Caliper.;Middle Arm Muscle Circumference (MAMC). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: MAMC = MAC – (3.1416 × TSF).	—

Measure

Time frame

Weight. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Digital scale.;Body Mass Index (BMI). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Weight (Kg)/height(m)2.;Middle Arm Circumference (MAC). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Tape.;Triceps skin fold (TSF). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Caliper.;Middle Arm Muscle Circumference (MAMC). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: MAMC = MAC – (3.1416 × TSF).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomayyeh Asghari

Tehran University of Medical Sciences

asghari.nut@gmail.com0098 21 889900285

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026