Metabolic syndrome. Metabolic syndrome
Conditions
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: Age between 30 and 50 years old Body mass index (BMI) ranged from 25 to 35 kg/m2 The presence of at least three of the five components of the metabolic syndrome according to the ATP III criteria including waist circumference greater than 102 cm in men and 88 cm in women, triglyceride equal to or greater than 150 mg/dL, HDL less than or equal to 40 in men and less than or equal to 50 In women, blood pressure equal to or greater than 130/85 mmHg and blood sugar equal to or greater than 100 mg/dL Willingness to participate in the study
Exclusion criteria
Exclusion criteria: Participate in weight loss programs over the past six months Weight change of more than 10% in the last six months Professional athletes or changes in the intensity and level of physical activity during the last four weeks Pregnant, lactating and postmenopausal women Allergy to dairy products and probiotics Smoking and alcohol consumption Routine consumption of products containing probiotics or synbiotics Diagnosed cardiovascular, kidney, gastrointestinal, endocrine, pulmonary, neurological, and autoimmune diseases; diabetes; thyroid dysfunction; cancer; and eating disorders. Taking medications that could affect appetite, body weight, and lipid metabolism or have anti-inflammatory effects such as corticosteroids, oral contraceptives, antidepressants and antipsychotics, anti-diabetics, statins, and other lipid-lowering drugs. Take antibiotics one month before the study begins Uncontrolled blood pressure Take probiotics and other dietary supplements within three months before the start of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting blood sugar. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Enzymatic method.;Insulin. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: ELISA.;Triglycerides. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Enzymatic.;ApoA1. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Immunoturbidometry.;ApoB. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Immunoturbidometry.;ApoA1/ApoB. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Blood concentration ratio ApoA1 / ApoB.;Atherogenic index of plasma (AIP). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: logTG/HDL formula.;Oxidized LDL (Ox-LDL). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: ELISA.;Blood pressure. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Mercury monometer.;Weight. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Digital scales.;Malondialdehyde (MDA). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Superoxide dismutase ( SOD). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Glutathione Peroxidase (GPX). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Total Oxidative status (TOS). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity (TAC). Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Insulin resistance index. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: HOMA-IR formula.;HDL cholesterol. Timepoint: Baseline and after 12 weeks of intervention. Method of measurement: Enzymatic.;Height. Timepoi | — |
Secondary
| Measure | Time frame |
|---|---|
| Energy and macronutrients intake. Timepoint: Baseline, 6th week, and at the end of the intervention. Method of measurement: Three day dietary recall questionnaire.;Physical activity. Timepoint: Baseline, 6th week, and at the end of the intervention. Method of measurement: International Physical Activity Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSomayyeh Asghari
Tehran University of Medical Sciences
Outcome results
None listed