The effect of dexmedetomidine on cardiovascular response

The effect of two different doses of dexmedetomidine intranasal on the cardiovascular response to laryngoscopy and endotracheal intubation

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220424054628N1

Enrollment

Registered

2022-04-30

Start date

2022-05-21

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular response after laryngoscopy and tracheal intubation.

Interventions

Intervention 1: Intervention group: 1 µg / kg dexmedetomidine intranasal at a concentration of 100 µg / ml in a 1cc syringe after injection of anesthetic drug. Intervention 2: Intervention group: 2 µ

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Elective surgery No airway abnormalities Requires endotracheal intubation under general anesthesia

Exclusion criteria

Exclusion criteria: History of allergy to the studied drug Difficult Airway Heart block in ECG BMI>30 History of obstruction of the nasopharyngeal ducts Pregnancy

Design outcomes

Primary

Measure	Time frame
Heart Rate. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: Cardiac monitor device.;Systolic blood pressure. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Diastolic blood pressure. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Mean arterial pressure. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Percentage of oxygen saturation. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: Pulse oximeter.	—

Measure

Time frame

Heart Rate. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: Cardiac monitor device.;Systolic blood pressure. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Diastolic blood pressure. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Mean arterial pressure. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Percentage of oxygen saturation. Timepoint: before induction of anesthesia and minutes 1, 3, 5, 10. Method of measurement: Pulse oximeter.

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Secondary

Measure	Time frame
Hypotension. Timepoint: Before induction of anesthesia, minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Hypertension. Timepoint: Before induction of anesthesia, minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Bradycardia. Timepoint: Before induction of anesthesia, minutes 1, 3, 5, 10. Method of measurement: Cardiac monitor device.;Tachycardia. Timepoint: Before induction of anesthesia, minutes 1, 3, 5, 10. Method of measurement: Cardiac monitor device.	—

Measure

Time frame

Hypotension. Timepoint: Before induction of anesthesia, minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Hypertension. Timepoint: Before induction of anesthesia, minutes 1, 3, 5, 10. Method of measurement: In millimeters of mercury using a calibrated barometer.;Bradycardia. Timepoint: Before induction of anesthesia, minutes 1, 3, 5, 10. Method of measurement: Cardiac monitor device.;Tachycardia. Timepoint: Before induction of anesthesia, minutes 1, 3, 5, 10. Method of measurement: Cardiac monitor device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzim Honarmand

Esfahan University of Medical Sciences

honarmand@med.mui.ac.ir+98 31 3662 4796

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026