Investigating the effect of topical diclofenac in diabetic macular edema

Comparison of clinical outcomes after combined therapy of bevacizumab intravitreal injection and topical diclofenac with bevacizumab intravitreal injection alone in diabetic macular edema

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220423054625N1

Enrollment

Registered

2023-10-28

Start date

2023-12-21

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic macular edema. Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema

Interventions

Intervention 1: Intervention group: Patients in the intervention group, in addition to receiving the standard treatment, which includes intravitreal injection of 1.25 mg of bevacizumab at the first vi

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Diabetic patients with non-proliferative diabetic retinopathy and diabetic macular edema Age over 18 years

Exclusion criteria

Exclusion criteria: Glaucoma patients Patients with a history of laser therapy Patients with significant media opacity Infection and inflammation of the anterior canine of the eye

Design outcomes

Primary

Measure	Time frame
Macula central thickness. Timepoint: Before the intervention and one and three months after the intervention. Method of measurement: Optical Coherence Tomography (OCT).;Visual acuity. Timepoint: Before the intervention and one and three months after the intervention. Method of measurement: Snellen chart.	—

Secondary

Measure	Time frame
Intraocular pressure. Timepoint: Before the intervention and one and three months after the intervention. Method of measurement: Tonometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Gader Motarjemizadeh

Oroumia University of Medical Sciences

gmotarjemizadeh@gmail.com+98 44 3245 7286

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026