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Efficacy of Alprazolam on blood pressure control

Comparison of the effect of oral captopril in comparison with alprazolam and oral captopril in controlling blood pressure in patients with urgent hypertension.

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220423054624N1
Enrollment
94
Registered
2022-05-25
Start date
2022-05-22
Completion date
Unknown
Last updated
2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Essential (primary) hypertension. Essential (primary) hypertension

Interventions

Intervention 1: Intervention group: In the intervention group, patients' blood pressure will be taken and recorded before the drug is administered lying down and the standard method using a mercury sp

Sponsors

Shahroud University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Systolic blood pressure over 180 or Diastolic blood pressure over 110 age between 18-80 years old Ability to understand and sign the conscientious informed consent No previous Allergy to Captopril or Alprazolam

Exclusion criteria

Exclusion criteria: Left Acute Heart Failure Chronic Renal Failure Cardiovascular disease History of stroke History of myocardial infraction Taking other Benzodiazepines in the last week Taking Muscle Relaxant drugs such as Baclofen Taking anti-anxiety drugs from other group such as Buspirone or Zolpidem Pregnant and Lactating women Occurring an emergency situation which indicates prescribing other Antihypertensive drug based on the Doctor's diagnosis Patients who have more than 15 mmHg difference in blood pressure between arms .

Design outcomes

Primary

MeasureTime frame
Systolic and diastolic blood pressure. Timepoint: checking blood pressure at the beginning of the study and then at 30 ,60 , 90 and 120 minutes after the intervention. Method of measurement: using a clinical mercury manometer device for monitoring the blood pressure in a standardized manner in which patient is lying down.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDR. Mohammadreza khorsand Kemachali

Shahroud University of Medical Sciences

dr_khorsandmd@yahoo.com+98 23 3239 5054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026