Acute Ischemic Stroke. Cerebral infarction due to thrombosis of unspecified precerebral artery
Conditions
Interventions
Intervention 1: Intervention group: prescribing fingolimod 0.5 miligrams at entrance and after 24 hours. Intervention 2: Control group: prescribing placebo at entrance and after 24 hours.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Acute onset focal neurologic deficit Age more then 18 years referring to hospital in less than 4.5 hours
Exclusion criteria
Exclusion criteria: Age more than 80 History of moderate or severe cardiovascular condition History of prior probable retinal problems Active viral or bacterial infection Suspicion of other neurologic conditions than CVA No existing hyperdense lesion in entry CT scan consisting with hemorrhagic lesion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale. Timepoint: At entrance , first month and 6th month after intervention. Method of measurement: Neurologic examination of neurologist.;The Modified Rankin Scale (mRS) for neurologic disability. Timepoint: Neurologic examination of neurologist. Method of measurement: The Modified Rankin Scale (mRS) for neurologic disability. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemorrhagic changes of stroke territory. Timepoint: 3th and 7th day after stroke. Method of measurement: CT scan by neurologist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamed Shahriyari
Tehran University of Medical Sciences
Outcome results
None listed