Major depressive disorder.
Conditions
Interventions
Intervention group:Two intervention groups and a sham group: One intervention group will receive one milliampere stimulation and the other two milliampere stimulation in the F3 and F4 areas, two twent
Sponsors
Qazvin University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) to be 18 to 60 years of age, (2) to fail to at least one antidepressant medication, (3) not to be on current antidepressant medication or having stable treatment regime for at least 4 weeks before the experiment, (4) unipolar depression diagnosis according to Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), criteria and confirmed by psychiatrists using the mini international Neuropsychiatric Interview (MINI), and (5) screened and qualified for brain stimulation interventions. Patients had to have a score of 17 points or more on the 17-item Hamilton Depression Rating Scale (HDRS; scores range from 0 to 52, with higher scores indicating more depression; a score of 24 or more indicates severe depression; minimal clinically significant difference, 3 points) as well as a low risk of suicide (evaluated with the use of the MINI). Other psychiatric or relevant neurological diseases and co-morbidities will be excluded.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Having any other psychiatric disorders, including bipolar, psychotic, and obsessive-compulsive spectrum disordersHaving a chronic medical condition Having epilepsy and other neurological disorders Having a history of head traumaUse of drugs and alcohol Having metal implants in the head Receiving psychological treatments for at least one month prior to entering the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression, transcranial electrical stimulation. Timepoint: Measurements of depression, working memory, social cognition, and risky decision-making before and after the intervention and three months after the intervention. Method of measurement: The Beck Depression Inventory (BDI-II) (for screening) and Hamilton (for measuring depression severity) are obtained, the Motor Orientation Test (MOT) is a training method designed to calm the client and introduce them to the computer and touch screen. It should always be administered at the beginning of the test session, the ERT for measuring social cognition, the CGT for risky decision-making, the SWM for working memory. | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression severity score, social cognition score, working memory score, risky decision-making score. Timepoint: Before and after the intervention and three months after the intervention. Method of measurement: To measure social cognition ERT To measure working memory WMS To measure risky decision-making CGT. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParinaz Sadat Amiri Sararudi
Qazvin University of Medical Sciences
Outcome results
None listed