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"The effect of probiotics in chronic periodontitis"

Comparison of the effectiveness of complementary therapy with probiotic mouthwash on clinical outcomes in patients with chronic periodontitis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220420054592N3
Enrollment
36
Registered
2025-07-17
Start date
2025-06-09
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis.

Interventions

Intervention 1: Intervention group: The group consuming mouthwash containing probiotics. the mouthwash is a combination of probiotic bacteria streptococcus salivarius M18 and streptococcus salivarius

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 60 Years

Inclusion criteria

Inclusion criteria: Have chronic periodontitis Age over 25 and under 60

Exclusion criteria

Exclusion criteria: No allergies to probiotics Not immunocompromised No systemic involvement with potential for periodontal involvement Not pregnant or breastfeeding No history of antibiotic therapy in the last 3 months No periodontal treatment in the last 6 months No smoking

Design outcomes

Primary

MeasureTime frame
Papillary bleeding index. Timepoint: In the first session and two weeks after using mouthwash (or probiotics or distilled water). Method of measurement: Place the periodontal probe 1 mm deep in the distal sulcus of the most posterior tooth in each quadrant on the buccal surface, then slowly move the probe along the sulcus from distal to mesial interproximal. Continue this for all teeth in the quadrant from the facial side, wait 30 seconds, and record the presence of bleeding on the distal, mesial, and facial surfaces on the chart. Repeat this on the lingual/palatal side and record the bleeding for the lingual surface. This will give you 4 separate numbers for each tooth. After recording all teeth, divide the number of bleeding surfaces by the total number of surfaces to get a percentage.;Plaque index. Timepoint: In the first session and two weeks after using mouthwash (or probiotics or distilled water). Method of measurement: The plaque index is a purely visual and subjective selection. Tablets and detector solutions are used to measure this index. We ask the patient to chew the tablet until it dissolves in saliva and spread it over the entire tooth surface with their tongue, remove the excess from the mouth and wait a while. If the detector is soluble, we use a small cotton swab dipped in the solution to apply it locally on the teeth. After a while, the areas with plaque will turn color. For each tooth, 4 levels are considered and the amount of color change of the spots relative to the entire tooth is calculated as a percentage.;Clinical attachment loss. Timepoint: In the first session and two weeks after using mouthwash (or probiotics or distilled water). Method of measurement: It is measured in millimeters with a periodontal probe, indicating the extent of periodontal support lost around the tooth.;Pocket depth. Timepoint: In the first session and two weeks after using mouthwash (or probiotics or distilled water). Method of measurement: It is measured using a gra

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArezoo Khabazian

Yazd University of Medical Sciences

arezookhabazian@yahoo.com+98 35 3625 5881

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026