Obesity. Obesity due to excess calories
Conditions
Interventions
Intervention 1: Intervention group:Get a ketogenic diet with calorie restriction for 8 weeks. Intervention 2: Control group: Get low calorie diet with calorie restriction for 8 weeks.
Sponsors
Vice chancellor for research, Shahid Beheshti University of Medical sciences- School of Nutrition
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Overweight or obese people between 18-60 years old Body mass index 40-26 kg / m2 Food addiction based on YFAS4 questionnaire Weight regain One-third to two-thirds of the weight lost in 1 year, or almost all of them in 5 years Do not be pregnant or breastfeeding
Exclusion criteria
Exclusion criteria: gout and chronic diseases such as diabetes, cardiovascular, liver, etc. mental illness (depression, bipolar disorder and obsessive-compulsive disorder) Failure to follow a specific diet take drugs that affect appetite and weight use any probiotic products in a recent month use antibiotics during the last month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: seca scale.;Body Mass Index. Timepoint: before intervention, 4 weeks and 8 weeks after intervention. Method of measurement: Calculation (kg/m2).;Waist circumference. Timepoint: before intervention, 4 weeks and 8 weeks after intervention. Method of measurement: Meter strip.;Fat Mass. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: Bio Impedance Analyzer.;Fat Free Mass. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: Bio Impedance Analyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum serotonin level. Timepoint: before intervention, 8 weeks after intervention. Method of measurement: Elisa.;Serum BDNF. Timepoint: before intervention, 8 weeks after intervention. Method of measurement: Elisa.;Gut microbiota. Timepoint: before intervention, 8 weeks after intervention. Method of measurement: PCR. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Zamanian
Shahid Beheshti University of Medical Sciences
Outcome results
None listed