The effect of two drugs, gabapentin and paroxetine, in improving psychological symptoms and quality of life in patients with gastrointestinal functional symptoms

Functional symptoms in UC patients in remission: a comparison of two antidepressants, Gabapentin and paroxetine, in the alleviating of functional gastrointestinal symptoms, psychological symptoms and quality of life

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220417054557N1

Enrollment

100

Registered

2023-05-20

Start date

2023-04-21

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ulcerative colitis in remission. Other ulcerative colitis without complications

Interventions

Intervention 1: Intervention group: Paroxetine recipient (20mg)- Exir company- The first week a quarter daily, the second week a half daily and the third week the full daily dose. Intervention 2: Inte

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Ulcerative colitis (UC) patients who are in remission Patients with functional gastrointestinal symptoms

Exclusion criteria

Exclusion criteria: pragnancy The presence of other gastrointestinal diseases Use of psychiatric drugs

Design outcomes

Primary

Measure	Time frame
Functional gastrointestinal symptoms. Timepoint: before the start of the intervention and after the completion of the intervention. Method of measurement: IBS symptom questionnaire.;Anxiety. Timepoint: before the start of the intervention and after the completion of the intervention. Method of measurement: HADS questionnaire.;Depression. Timepoint: before the start of the intervention and after the completion of the intervention. Method of measurement: HADS questionnaire.;Quality of life. Timepoint: before the start of the intervention and after the completion of the intervention. Method of measurement: sf-36 questionnaire.	—

Measure

Time frame

Functional gastrointestinal symptoms. Timepoint: before the start of the intervention and after the completion of the intervention. Method of measurement: IBS symptom questionnaire.;Anxiety. Timepoint: before the start of the intervention and after the completion of the intervention. Method of measurement: HADS questionnaire.;Depression. Timepoint: before the start of the intervention and after the completion of the intervention. Method of measurement: HADS questionnaire.;Quality of life. Timepoint: before the start of the intervention and after the completion of the intervention. Method of measurement: sf-36 questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarahnaz Safaei

Shahid Beheshti University of Medical Sciences

farahnazsafayii@gmail.com+98 21 23871

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026