Distal esophageal spasm. Dyskinesia of esophagus
Conditions
Interventions
Intervention 1: The first group will be treated with fluoxetine 10 mg daily and omeprazole 20 mg every 12 hours for 2 months. Completion of questionnaires and esophageal manometry will be done before
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age more than 18 years All patients diagnosed as distal esophageal manometry according to manometry
Exclusion criteria
Exclusion criteria: 1. Patients abusing drugs 2. Patients with systemic disorders including :Mastocytosis Systemic vasculitis, Sarcoidosis, Hypothyroidism, Diabetes mellitus, Fibromyalgia, Adrenal insufficiency, Coeliac disease, inflammatory bowel disease, Hypertension (high blood pressure), Metabolic syndrome, AIDS, Graves' disease, Systemic lupus erythematosus, Rheumatoid arthritis, Atherosclerosis, Sickle cell disease, Myasthenia gravis, Systemic Sclerosis, Sinusitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of clinical manifestations (chest pain, dysphagia). Timepoint: Before intervention and 2 months after intervention. Method of measurement: Questionnaire of patients symptoms, Questionnaire of quality of life, Eckardt score, Psychological questionnaire HADS and SF-36, esophageal manometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of esophageal manometric parameters. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Esophageal manometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAhmad Ghorbanpour Rasekh
Shahid Beheshti University of Medical Sciences
Outcome results
None listed