Female Infertility. Female infertility
Conditions
Interventions
Intervention 1: Intervention group: Women candidates for IUI who will receive a single dose of Letrozole 20 mg tablet. Intervention 2: Control group: Women candidates for IUI who will receive 5 mg of
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Have a history of at least one year of infertility Absence of underlying disease including abnormal thyroid stimulating hormone prolactin Spermogram within acceptable range for IUI At least one fallopian tube is open.
Exclusion criteria
Exclusion criteria: History of allergy to letrozole and other aromatase inhibitors History of allergy to cabergoline and other ergot derivatives History of pelvic surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ovarian response (the number of follicle with size more than 14 millimeter). Timepoint: The day 9 to 11 of menstruation cycle. Method of measurement: Vaginal ultrasound.;Ovarian response (the size of biggest follicle). Timepoint: The day 9 to 11 of menstruation cycle. Method of measurement: Vaginal ultrasound.;Endometrial thickness. Timepoint: The day 9 to 11 of menstruation cycle. Method of measurement: Vaginal ultrasound.;The number of HMG ampoules required. Timepoint: from day 11 to 13 menstruation cycle. Method of measurement: Medical record. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy (Positive BHCG test). Timepoint: Two weeks after IUI (intra uterine insemination). Method of measurement: Blood test.;Abortion. Timepoint: During 3 months after pregnancy confirmation. Method of measurement: Getting out of pregnancy products (direct observation or ultrasound). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Hashemi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed