Obstructive Sleep Apnea (OSA). Obstructive sleep apnea (adult) (pediatric)
Conditions
Interventions
Intervention group: Patients with obstructive sleep apnea syndrome who are treated with CPAP device. Control group: Healthy people (no obstructive sleep apnea syndrome) without intervention.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients who have been diagnosed with obstructive sleep apnea syndrome after a sleep test.
Exclusion criteria
Exclusion criteria: People who have a background of respiratory disease (other than apnea). People with a history of malignancy. People with a history of cardiovascular disease. People with a history of neurological diseases (such as neurodegenerative diseases, epilepsy and head trauma). People who abuse alcohol or drugs or take psychotropic drugs while studying. People who have structural lesions in the brain. People who, in addition to obstructive sleep apnea, also have hypoventilation syndrome. People with metabolic diseases (such as polycythemia). Patients who, after PSG and clinical tests, are diagnosed as not candidates for CPAP treatment. People who have contraindications to MRI scans (such as people with cardiac pacemakers and metal implants or even people with a fear of closed space (Claustrophobia)).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain Cortical Thickness. Timepoint: Before treatment, 6 months after treatment. Method of measurement: Analysis of structural MR images.;Functional connection of brain areas (rsFC). Timepoint: Before treatment, 6 months after treatment. Method of measurement: Analysis of functional MR images.;Oxygen Extraction Fraction (OEF). Timepoint: Before treatment, 6 months after treatment. Method of measurement: Analysis of structural MR images. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammad Ali Oghabian
Tehran University of Medical Sciences
Outcome results
None listed