Cardiometabolic syndrome. Metabolic syndrome
Conditions
Interventions
Intervention 1: Intervention group: The intervention group will consume 1 synbiotic capsule daily for 12 weeks. Each capsule will contain a specific dose of probiotics (equivalent to 10^9 CFU of each
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
5 Years to 18 Years
Inclusion criteria
Inclusion criteria: Willingness to cooperate and sign the informed consent form after full knowledge of the objectives and methods of the study. Girls and boys aged 5 to 18 years. Diagnosis of cardiometabolic syndrome based on common criteria (presence of at least three of the following: central obesity, insulin resistance, high blood pressure, blood lipid disorders). Absence of acute or chronic gastrointestinal diseases that may affect the composition of the gut microbiome. No substance abuse, no hormone therapy, no recent weight loss diet. No pregnancy or breastfeeding in women. Do not take medications or supplements that affect appetite, weight, or metabolism for at least 6 months before the study (such as medications that affect carbohydrate, protein, or fat metabolism, and medications that reduce or increase appetite or food intake, including herbal supplements). No history of gastrointestinal surgery. Avoid concomitant use of metabolism-related medications or probiotics, such as antibiotics.
Exclusion criteria
Exclusion criteria: Having any acute illness. The occurrence of any accident that affects a person's health. Acceptance rate less than 80%. Immigration. Exclusion based on personal preference of participants or their parents. Changes in medications taken during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: Beginning and end of the study. Method of measurement: scale.;Serum glucose levels. Timepoint: Beginning and end of the study. Method of measurement: Laboratory kit.;Serum triglyceride level. Timepoint: Beginning and end of the study. Method of measurement: Laboratory kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mass index. Timepoint: Beginning and end of the study. Method of measurement: Calculation.;Serum C-Reactive Protein (CRP) levels. Timepoint: Beginning and end of the study. Method of measurement: Laboratory kit.;Systolic blood pressure. Timepoint: Beginning and end of the study. Method of measurement: blood pressure monitor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPejman Rohani
Tehran University of Medical Sciences
Outcome results
None listed