Evaluation of the outcome of ART in dual trigger method compared to the usual method in poor responder patients

Comparison of ART outcome in DUAL Trigger method in POOR RESPONDER individuals in GnRH Antagonist cycles in comparison with the usual method (Single trigger) in the infertility center of Arash Women's Comprehensive Hospital

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220409054458N1

Enrollment

Registered

2022-06-25

Start date

2022-06-21

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility in poor responder patients. Female infertility

Interventions

Intervention 1: Intervention group: after reaching at least 2 eggs with a diameter of 17 mm, the DUAL trigger group is treated with HCG 5000IU and GnRH Agonist (VARIOPEPTYL 0.1 mg subcutaneously) and

Eligibility

Sex/Gender

Female

Age

30 Years to 42 Years

Inclusion criteria

Inclusion criteria: All poor responder patients according to BOLOGNIA criteria who are ART candidates and are in GnRH Antagonist cycle.

Exclusion criteria

Exclusion criteria: Grade 3 and 4 endometriosis Hydrosalpinx Endocrine disorders such as hyperprolactinemia, thyroid and adrenal problems Azoospermia

Design outcomes

Primary

Measure	Time frame
The number of oocytes obtained in the ovulation stimulation cycle. Timepoint: Number of oocytes obtained after ovarian puncture in the ovulation stimulation cycle. Method of measurement: Count the number of oocytes obtained per cycle.	—

Secondary

Measure	Time frame
Chemical pregnancy rate. Timepoint: 2 weeks after oocyte transfer into the uterus. Method of measurement: Serum BHCG level.;Clinical pregnancy rate. Timepoint: 5 weeks after oocyte transfer into the uterus. Method of measurement: Vaginal ultrasound examination of the pregnancy sac.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZakieh Musazadeh Fatidehi

Tehran University of Medical Sciences

Zakiyeh.1991@gmail.com+98 21 7788 3283

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026