coronary heart disease. Ischaemic heart diseases
Conditions
Interventions
Intervention 1: The intervention group: Patients are selected based on the inclusion and exclusion criteria and undergo ischemia induced by a sphygmomanometer cuff (RIPC + RIPostC) an hour prior to an
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age range 18 years and above Patients who have undergone on-pump heart surgery and Blood cardioplegia has been used to prevent myocardial injury during ischemia. Patients with EF levels above 30% Patients in whom 3 to 4 coronary arteries are grafted. All patients are operated only by one cardiac surgeon. Both men and women can participate Be able to fill out the consent form.
Exclusion criteria
Exclusion criteria: Age under 18 years History of malignancy during the last 5 years permanent Flutter and atrial fibrillation Patients undergoing off-pump heart surgery Cardiogenic shock Cardiac arrest Significant peripheral artery disease Patients with a systolic blood pressure greater than 160 mm Hg Liver failure (bilirubin above 20 µmol / L or 1.2 mg / dL and INR above 2.0) Pulmonary disease (FEV1 <40%) Renal insufficiency (GFR less than 30ml per minute per 1.73 m2) Concomitant treatment with glibenclamide and nicorandil Unable to fill out consent form Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of blood level of CK-MB enzyme. Timepoint: On admission, 12 , 24 , 48 and 72 hours after surgery. Method of measurement: patient tests.;2- Determination of blood level of cardiac troponin enzyme. Timepoint: On admission, 12, 24 , 48 and 72 hours after surgery. Method of measurement: patient tests.;Cardiac function. Timepoint: 7 and 40 days after surgery. Method of measurement: Based on echocardiographic results.;Incidence of cardiac dysrhythmias. Timepoint: 72 hours after surgery. Method of measurement: Electrocardiogram.;Determination of the frequency of acute renal injury (AKI). Timepoint: 24, 48 and 72 hours after surgery. Method of measurement: Based on RIFLE criteria and patient test results.;Determination the amount of base deficit in arterial blood. Timepoint: On admission,1 and 2 days after the operation. Method of measurement: patient tests.;Lactate. Timepoint: On admission, 1 and 2 days after the operation. Method of measurement: patient tests.;Liver Enzymes. Timepoint: On admission, 1,2 and 3 days after the operation. Method of measurement: patient tests.;Duration of postoperative mechanical ventilation. Timepoint: After detachment from the ventilator. Method of measurement: patients record.;Duration of hospitalization in the ICU. Timepoint: Upon completion of hospitalization in the ICU. Method of measurement: patients record.;Duration of hospitalization. Timepoint: at discharge. Method of measurement: patients record. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac Complications (ECG Changes and hemodynamic Status). Timepoint: On admission to 72 hours after surgery. Method of measurement: EKG.;Blood indicators: electrolyte changes, blood, allergic , liver and renal complications. Timepoint: Patient tests. Method of measurement: On admission to 72 hours after surgery. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlimohammad sadeghi meibodi
Rasht University of Medical Sciences
Outcome results
None listed