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Comparison of prophylactic effect single-dose Celecoxib and Mefenamic acid

Comparison of prophylactic effect of single-dose Celecoxib and Mefenamic acid in reducing pain after tooth extraction

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220407054442N1
Enrollment
150
Registered
2022-07-30
Start date
2022-07-01
Completion date
Unknown
Last updated
2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth extraction.

Interventions

Intervention 1: First intervention group: Patients that receiving a single dose of celecoxib 200 mg capsules. Intervention 2: second intervention group: Patients receiving a single dose of Mefenamic a

Sponsors

Shahre-kord University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
14 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 14 years and of any sex who do not have a serious systemic disease and are classified in class 1 or 2 of The American Society of Anesthesiologists (ASA) will be included in this study.

Exclusion criteria

Exclusion criteria: Patients who referred for tooth extraction due to periodontal support problem will not be included in the study. Patients with symptoms of infection such as swelling, fever, pus discharge, and decreased mouth opening will also not be included in the study. Patients who need analgesics for any reason other than toothache will not be included in the study. Patients who have a history of taking any painkillers up to 12 hours before tooth extraction will not be included in this study. Patients with systemic physical or mental illness or at risk for infectious endocarditis, coagulation problems, local and systemic infections, known allergies to celecoxib or mefenamic acid, a history of asthma, or drug or alcohol addiction will not be included in this study. Patients who require severe surgical intervention to extract a tooth will not be included in this study. celecoxib is contraindicated in patients with heart problems. Therefore, patients with heart disease will not participate in this study.

Design outcomes

Primary

MeasureTime frame
Pain score in Visual Analogue Scale score questionnaire. Timepoint: Measure the amount of pain in one, three and six hours after tooth extraction. Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmin Samimi

Shahre-kord University of Medical Sciences

amin1samimi@gmail.com+98 31 3781 6798

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026