The effect of probiotics on intestinal microbiota

Effect of probiotic supplementation on gut microbiota in patients with food addiction and weight regain after bariatric surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220406054437N2

Enrollment

Registered

2022-11-14

Start date

2022-08-06

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Food addiction, Weight regain after bariatric surgery.

Interventions

Intervention 1: Intervention group: Participants take 2 Multi-strain probiotic capsules daily (after breakfast and after lunch) for 12 weeks. All individuals are given a hypocaloric (-300 to 500 kcal

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: At least 18 months have passed since the date of bariatric surgery and having weight regain of at least 10% of the lowest weight gained Confirmation of food addiction with yale food addiction scale (YFAS) Being in the age range of 18-50 years

Exclusion criteria

Exclusion criteria: Pregnancy, lactation, menopause professional athlete Use of any type of antibiotic in the last three weeks Using any type of probiotic product or protein supplement in the last month Having liver diseases (other than fatty liver), kidney, cancer and thyroid diseases Use of weight loss and appetite suppressants

Design outcomes

Primary

Measure	Time frame
Bacteroides Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Lactobacillus Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Bifidobacterium Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Megamonas Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Eubacterium Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Akkermansia Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.	—

Measure

Time frame

Bacteroides Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Lactobacillus Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Bifidobacterium Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Megamonas Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Eubacterium Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.;Akkermansia Abundance in the stool sample. Timepoint: At the beginning of the study and 12 weeks later. Method of measurement: Polymerase chain reaction (PCR) in stool samples.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAtoosa Saidpour

Shahid Beheshti University of Medical Sciences

Atoosa.Saidpour@gmail.com+98 21 2207 7425

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026