Comparison of the effect of 23% and 28% hematocrit blood supplementation on lactate in pediatric non-cyanotic heart surgery patients

Comparison of the effect of blood prime with target hematocrit 23 or 28% on lactate in non-cyanotic pediatric cardiac surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220405054424N1

Enrollment

100

Registered

2022-05-12

Start date

2021-09-26

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-cyanotic cardiac disease.

Interventions

Intervention 1: Intervention group: In this study, patients are implanted with arterial line after induction of anesthesia and intubation, also central vein is implanted for the patient, then they ar

Eligibility

Sex/Gender

All

Age

4 Months to 5 Years

Inclusion criteria

Inclusion criteria: Children weighing 7-17 kg Non-cyanotic disease Candidates for cardiac surgery

Exclusion criteria

Exclusion criteria: Patients who received blood before surgery Emergency surgery Re operation Open heart surgery

Design outcomes

Primary

Measure	Time frame
Lactate. Timepoint: Lactate levels are measured at the beginning of the operation, after going to the cardiopulmonary bypass, at the end of the operation and 24 hours after the operation in the intensive care unit. Method of measurement: Check lactate level with arterial blood gas sample.	—

Secondary

Measure	Time frame
Comparison of HCO3 changes. Timepoint: It is measured at the beginning of surgery and at the end of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial Blood Gas sample.;Comparison of BE changes. Timepoint: It is measured at the beginning of surgery and at the end of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial Blood Gas sample.;Comparison of the need to receive PC in both groups in the operating room and the first 24 in the intensive care unit. Timepoint: It is measured at the beginning of surgery and at the end of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial Blood Gas sample.;Comparison of proBNP changes in both group. Timepoint: It is measured at the beginning of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial Blood Gas sample.;Comparison of ionic changes during and after surgery in both groups. Timepoint: It is measured at the beginning of surgery and at the end of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial blood gas sample.	—

Measure

Time frame

Comparison of HCO3 changes. Timepoint: It is measured at the beginning of surgery and at the end of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial Blood Gas sample.;Comparison of BE changes. Timepoint: It is measured at the beginning of surgery and at the end of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial Blood Gas sample.;Comparison of the need to receive PC in both groups in the operating room and the first 24 in the intensive care unit. Timepoint: It is measured at the beginning of surgery and at the end of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial Blood Gas sample.;Comparison of proBNP changes in both group. Timepoint: It is measured at the beginning of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial Blood Gas sample.;Comparison of ionic changes during and after surgery in both groups. Timepoint: It is measured at the beginning of surgery and at the end of surgery and 24 hours later in the intensive care unit by the patient's arterial blood sample. Method of measurement: Arterial blood gas sample.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemehshima Hadipoorzadeh

Iran University of Medical Sciences

m_ghadimi@sums.ac.ir+98 21 2392 2417

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026