Evaluation of the effectiveness of with different types of anticoagulants treatment in patients with atrial fibrillation in one-year follow-up in preventing stroke and bleeding complications

Evaluation of the effectiveness of with different types of anticoagulants treatment in patients with atrial fibrillation in one-year follow-up in preventing stroke and bleeding complications comparison of drugs warfarin rivaroxaban and apixaban

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220404054402N1

Enrollment

198

Registered

2022-06-10

Start date

2022-06-21

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation. Chronic atrial fibrillation

Interventions

Intervention 1: Intervention group: 15-20 mg oral rivaroxaban once daily for 1 year (Arena Hayat Danesh company). Intervention 2: Intervention group: 2.5-5 mg oral apixaban twice daily for 1 year (Are

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age > 18 years Diagnosis of atrial fibrillation Informed consent to participate in the study Elevated CHA2DS2-VASc score of 2 or greater in men or 3 or greater in women

Exclusion criteria

Exclusion criteria: Patients treated with multiple oral anticoagulants Taking multiple doses of the drug Taking drugs with indications other than prevention of stroke and hemorrhage Loss to follow-up before 1 year Patients without comorbidity known to be associated with higher mortality such as heart failure, cancer, chronic pulmonary disease

Design outcomes

Primary

Measure	Time frame
Minor and major bleeding. Timepoint: First after 6 months after 12 months. Method of measurement: Physical exam,Hemoglobin,Pletlet and Coagulation test.;Ischemic stroke and Systemic embolism. Timepoint: First after 6 months after 12 months. Method of measurement: Physical exam.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Khademi

Ahvaz University of Medical Sciences

zahrakhademi157@gmail.com+98 61 3333 3477

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026