Evaluation of the effectiveness of Chlorhexidine and sodium bicarbonate mouthwash solutions on the onset of Covid-19 symptoms

Comparative study of the effect of two solutions of Chlorhexidine and sodium bicarbonate mouthwash on the onset of Covid-19 related symptoms in vaccinated operating room staff

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220328054364N1

Enrollment

120

Registered

2022-06-21

Start date

2022-07-06

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid-19. SARS-associated coronavirus as the cause of diseases classified elsewhere

Interventions

Intervention 1: In intervention group 1, after preparing dark colored medicine glass bottles that are uniform, the researcher prepares 0.2% Chlorhexidine solution under the brand name Vi-one in the fo

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Personnel with an age range of 18-60 years Get at least two doses of the vaccine At least two weeks have passed since the second dose of the vaccine was given

Exclusion criteria

Exclusion criteria: Pregnant personnel Breastfeeding period History of allergy to mouthwash solutions Taking immunosuppressive drugs Having Covid-19 in the last two months Having symptoms of systemic infection

Design outcomes

Primary

Measure	Time frame
Headache. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Temperatures. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Medical thermometer (Record in the checklist of symptoms).;Cough. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Shortness of breath. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Muscular pain. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Sore throat. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Runny nose and nasal congestion. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Sneezing. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Lethargy. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Dizziness. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Anorexia. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Diarrhea. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Vomit. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Decreased sense of taste. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Decreased sense of smell. Timepoint: For 4 weeks, from the	—

Measure

Time frame

Headache. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Temperatures. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Medical thermometer (Record in the checklist of symptoms).;Cough. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Shortness of breath. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Muscular pain. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Sore throat. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Runny nose and nasal congestion. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Sneezing. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Lethargy. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Dizziness. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Anorexia. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Diarrhea. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Vomit. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Decreased sense of taste. Timepoint: For 4 weeks, from the beginning of using mouthwash. Method of measurement: Record in the checklist of symptoms.;Decreased sense of smell. Timepoint: For 4 weeks, from the

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHanieh Karami Chamgordani

Esfahan University of Medical Sciences

haniehkarami@nm.mui.ac.ir+98 31 3792 7516

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026