multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group1: Pilates Exercise Group Outdoors Intervention.15 people performed an exercise program for eight weeks (three sessions per week, each session one hour). The exercise
Sponsors
The University of Hakim Sabzevari
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: at least two years of history EDSS between 2 and 5 no smoking, no regular exercise
Exclusion criteria
Exclusion criteria: Muscle injuries Severe relapse of the disease disability to perform sports exercises Lack of regular participation in the training protocol Participate in a training program other than the research training protocol, Pregnancy relapse of MS in the last 12 weeks Change in MS medication or steroid treatment in the last 12 weeks and period of practice Lack of cooperation until the end of the research process
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Assess fatigue status. Timepoint: Before the intervention and 2 days after the intervention. Method of measurement: By the Fatigue Severity Scale (FSS) Questionnaire.;Evaluation of Quality of life. Timepoint: 48 hours before and 48 hours after the study. Method of measurement: By multiple sclerosis Quality of life-54 (MSQOL-54) Questionnaire.;Evaluation of deppresion. Timepoint: 48 hours before and 48 hours after the study. Method of measurement: questionnaires Depression, Anxiety, Stress Scales (DASS-21).;Physical function based on 6 minutes walking time. Timepoint: 48 hours before and 48 hours after the study. Method of measurement: Measurement of physical function (cardiorespiratory endurance) by 6-minute walking test. | — |
Primary
| Measure | Time frame |
|---|---|
| Blood serum vitamin D status. Timepoint: 48 hours before and 48 hours after the intervention. Method of measurement: enzyme-linked immunosorbent assay (ELISA) by the Kit.;The inflammatory status of axonal damage (Neurofilament light chain). Timepoint: 2 days before the intervention and 2 days after the intervention. Method of measurement: enzyme-linked immunosorbent assay (ELISA) by the Kit.;Status of neuroprotective metabolites in the kynurenine pathway (kynurenine and kynurenic acid). Timepoint: 48 hours before and 48 hours after the intervention. Method of measurement: Liquid chromatography–mass spectrometry (LC–MS).;Status of neurodegenerative metabolite in the kynurenine pathway (quinolinic acid). Timepoint: 48 hours before and 48 hours after the intervention. Method of measurement: Liquid chromatography–mass spectrometry (LC–MS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Roya askari
The University Of Hakim Sabzevari
Outcome results
None listed