Effect of rTMS with and without CCR in treatment of the bipolar disorder

Comparison of the effectiveness of transcranial magnetic stimulation (TMS) therapy with and without computer-based cognitive rehabilitation (CCR) in the brain signal of patients with bipolar disorder

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220321054335N1

Enrollment

Registered

2022-10-29

Start date

2022-09-06

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bipolar Disorder. Bipolar disorder

Interventions

Intervention 1: Intervention group: Bilateral rTMS

The coil will locate on F3 and F4 in accordance with the 10-20 international system. Bilateral rTMS include stimulate the right DLPFC at 1 Hz for a 10 seconds train of stimulation, and a total of 900

In this group, the same TMS protocol as the first group will be used, and after a short break from the end of the TMS session, they will receive attention and memory exercises according to their level

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All adults diagnosed with bipolar disorder by psychologists and psychiatrists Minimum education in reading and writing

Exclusion criteria

Exclusion criteria: History of epilepsy or convulsions in the person or first degree relatives Having acute heart disease No history of drug use and head trauma Pregnant or breastfeeding women The presence of intracranial implants (such as shunts, electrodes) or any other metal object in or near the head (such as the mouth) Having a pacemaker

Design outcomes

Primary

Measure	Time frame
The score of Bipolar Depression Rating Scale (BDRS). Timepoint: Evaluation of mood symptoms before the start of the intervention and after the last session of TMS and CCR treatment. Method of measurement: Bipolar Depression Rating Scale (BDRS).;Evaluation of cognitive functions by Cantab. Timepoint: Evaluation of cognitive functions before the start of the intervention and after the last session of TMS and CCR treatment. Method of measurement: the Cambridge Neuropsychological Test Automated Battery (CANTAB) will be used.;Power of frequency bands in rest condition and changes of P300 component during Go-NoGo task (using Mitsar EEG recording device). Timepoint: Evaluation of brain signal before the start of the intervention and after the last session of TMS and CCR treatment. Method of measurement: by 19-channel EEG device during rest and Go-NoGo task.	—

Measure

Time frame

The score of Bipolar Depression Rating Scale (BDRS). Timepoint: Evaluation of mood symptoms before the start of the intervention and after the last session of TMS and CCR treatment. Method of measurement: Bipolar Depression Rating Scale (BDRS).;Evaluation of cognitive functions by Cantab. Timepoint: Evaluation of cognitive functions before the start of the intervention and after the last session of TMS and CCR treatment. Method of measurement: the Cambridge Neuropsychological Test Automated Battery (CANTAB) will be used.;Power of frequency bands in rest condition and changes of P300 component during Go-NoGo task (using Mitsar EEG recording device). Timepoint: Evaluation of brain signal before the start of the intervention and after the last session of TMS and CCR treatment. Method of measurement: by 19-channel EEG device during rest and Go-NoGo task.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Rostami

University of Tehran

rezaros@gmail.com+98 21 8401 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026