infertility. Female infertility, unspecified
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, women with recurrent implant failure, in addition to receiving drugs (including: folic acid, vitamin D3, B complex and probiotics) and st
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 41 Years
Inclusion criteria
Inclusion criteria: Infertile women aged 18-41 years Infertile IVF candidate women with a history of failure twice Women with endometrium suitable for embryo transfer Women with good quality embryos for transfer Women who have passed 2 months or more since the last ICSI test and transfer. Women who have the opportunity to attend the follow-up according to the plan and have informed consent Women with a normal size and shape of the uterus that has been confirmed by ultrasound or hysteroscopy
Exclusion criteria
Exclusion criteria: Patients who use nitrite or organic nitrate at the same time Women with chronic diseases such as: severe liver, kidney, or cardiovascular failure, patients with a history of stroke or myocardial infarction Women smokers Women with stage 3 and 4 endometriosis Women with a known etiology of implant failure such as anatomical disorders (diagnosed by hysterosalpingography), hormonal disorders, immunological disorders, trophoblasts, antiphospholipid antibodies, mutation in factor V, pro-thrombin, crew disorders Musomes are excluded from the study Patients with side effects of L-arginine Canceling the treatment cycle for any reason Unwillingness of the person to continue participating in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uterine vascular resistance. Timepoint: At the beginning of the intervention and after taking L-arginine. Method of measurement: Color Doppler ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy. Timepoint: After taking the drug and transferring the fetus. Method of measurement: B-HCG titration test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShamim Pilehvari
Hamedan University of Medical Sciences
Outcome results
None listed