The effect of dexmedetomidine on hemodynamic changes in patients undergoing coronary artery bypass graft

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220316054311N1

Enrollment

Registered

2022-03-24

Start date

2021-12-22

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery bypass graft. Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris

Interventions

Intervention 1: Intervention group: In the dexmedetomidine group, one dose of the drug at 0.5 mcg/kg will be injected intravenously within 10 min. Intervention 2: Control group: They will receive no d

Eligibility

Sex/Gender

All

Age

30 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age 30-80 years American Society of Anesthesiologists (ASA) class II, III, and IV Candidates of elective coronary artery bypass graft (CABG) with cardiopulmonary bypass (CPB)

Exclusion criteria

Exclusion criteria: Emergency surgery Ejection fraction <30% Concurrent valvular sugery Any complication during surgery and pacemaker requirement

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.	—

Secondary

Measure	Time frame
Mean arterial pressure. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Systemic vascular resistance. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Cardiac output. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Heart rate. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Central venous pressure. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Cross clamp time. Timepoint: During surgery. Method of measurement: Clinical assessment.;Pump time. Timepoint: During surgery. Method of measurement: Clinical assessment.;Inotrope requirement. Timepoint: During surgery. Method of measurement:	—

Measure

Time frame

Mean arterial pressure. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Systemic vascular resistance. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Cardiac output. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Heart rate. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Central venous pressure. Timepoint: Baseline, before sternotomy, immediately after sternotomy and then at 10, 20, 30, 40, 50, and 60 min, before CPB, before cross clamp removal, before weaning, after weaning, before sternal closure, after sternal closure, at 1, 2, 3, 4, 5, and 6 hour in the intensive care unit. Method of measurement: Monitoring device.;Cross clamp time. Timepoint: During surgery. Method of measurement: Clinical assessment.;Pump time. Timepoint: During surgery. Method of measurement: Clinical assessment.;Inotrope requirement. Timepoint: During surgery. Method of measurement:

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mohammad Abtahi

Bandare-abbas University of Medical Sciences

abtahi_mohamad@yahoo.com+98 76 3334 5009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026