Effect of topical Latanoprost combined with microneedling in the treatment of alopecia areata

Investigation of the efficacy of topical latanoprost 0.005% combined with microneedling in comparisson to microneedling in the treatment of the patients with scalp patchy alopecia areata

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220316054304N1

Enrollment

Registered

2022-09-05

Start date

2022-09-03

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

alopecia areata. other alopecia areata

Interventions

Intervention 1: Intervention side: Under aseptic precaution microneedling is performed by Dr.pen ULTIMA-A6 manufactured in USA. The device is an automated microneedling device, with 12pins cartridge.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: age> 18 years old AA coverage <25% of scalp surface presence of 2-5 patches discontinue of intralesional triamcinolone treatment at least 2 weeks earlier stable disease without the appearance of a new patch or increase in the size of the patches for at least 15 days

Exclusion criteria

Exclusion criteria: allergy or hypersensitivity to any component of treatment products pregnancy or lactation any skin infection on treatment area severe medical illness simultaneous use of immunosuppressant or anticoagulant medication progressive disease posetive hair pull test

Design outcomes

Primary

Measure	Time frame
Terminal hair growth change. Timepoint: The patients will be assessed in 2 every 2 weeks visits for procedures, and 3 months after the first visit. Method of measurement: ?Terminal hair growth change garde into following 6 grade:Grade 0:no change or further hair loss /Grade 1: regrowth of 1-24% terminal hair /Grade 2: regrowth of 25-49% terminal hair /Grade 3: regrowth of 50-74% terminal hair /Grade 4: regrowth of 75-99% terminal hair /Grade 5:regrowth of 100% terminal hair.	—

Measure

Time frame

Terminal hair growth change. Timepoint: The patients will be assessed in 2 every 2 weeks visits for procedures, and 3 months after the first visit. Method of measurement: ?Terminal hair growth change garde into following 6 grade:Grade 0:no change or further hair loss /Grade 1: regrowth of 1-24% terminal hair /Grade 2: regrowth of 25-49% terminal hair /Grade 3: regrowth of 50-74% terminal hair /Grade 4: regrowth of 75-99% terminal hair /Grade 5:regrowth of 100% terminal hair.

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Secondary

Measure	Time frame
Rate of patch size change. Timepoint: ?The patients will be assessed in 2 every 2 weeks visits for procedures, and 3 months after the first visit. Method of measurement: Rate of size change (%)= Baseline size-Follow up size/Baseline size ×???.;Patient satisfaction. Timepoint: ?The patients will be assessed in 2 every 2 weeks visits for procedures, and 3 months after the first visit. Method of measurement: A 5-point scale. 4: Extremely satisfied, 3:Very satisfied, 2: satisfied, 1: Slightly satisfied, 0: Not satisfied.	—

Measure

Time frame

Rate of patch size change. Timepoint: ?The patients will be assessed in 2 every 2 weeks visits for procedures, and 3 months after the first visit. Method of measurement: Rate of size change (%)= Baseline size-Follow up size/Baseline size ×???.;Patient satisfaction. Timepoint: ?The patients will be assessed in 2 every 2 weeks visits for procedures, and 3 months after the first visit. Method of measurement: A 5-point scale. 4: Extremely satisfied, 3:Very satisfied, 2: satisfied, 1: Slightly satisfied, 0: Not satisfied.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Sadati

Shiraz University of Medical Sciences

Msadati63@yahoo.com+98 71 3212 5239

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026