Osteoarthritis of knee. Unilateral primary osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: 0.5 miligram per kilogram of body weight ketamine in 5 cc syringe and increase to total volume of 5ml with normal saline. after spinal anesthesia and before incisi
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Between 18 and 85 years old undergoing unilateral, primary total knee arthroplasty "TKA" for degenerative end-stage osteoarthritis(OA) of the knee (score of >2 on Kellgren-Lawrence scale).
Exclusion criteria
Exclusion criteria: patients who refuse to participate, classified as ASA IV or V by the American Society of Anesthesiologists, body mass index greater than 40 kg/m2, rheumatoid arthritis, contraindication or allergy to opioid pain medications allergy to amide or sulpha anesthetics, unable to understand the visual analog scale (VAS) , any preoperative ketamine or chronic narcotic usage (>10mg systemic morphine equivalents daily ) as it causes opioids tolerance , those who are discharged before the first 24 hours postoperatively, previous history of knee arthroplasty, prior surgery on the ipsilateral knee within 6 months, simultaneous bilateral arthroplasty, the patients receiving general anesthesia or a nerve block patients with an ejection fraction of less than 30%, creatinine clearance of less than 30mL/min, chronic liver disease, any neurologic or psychiatric disorder (including bipolar,post-traumatic stress disorder, schizophrenia), chronic alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: 2 hour , 6hour , 12 hour ,24 hour ,10 days ,42 days post operative. Method of measurement: Visual Analogue Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum post op knee flexion. Timepoint: at discharge ,post op day 10 , post op day 42. Method of measurement: orthopedic ruler.;Hospital stay duration. Timepoint: from the end of operation to discharge time. Method of measurement: time-hour.;Time of first morphine request. Timepoint: from the end of operation to first time of morphine request. Method of measurement: time-hour.;Total morphine(analgesics) consumption. Timepoint: at the time of discharge. Method of measurement: mg/kg....patient document. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSina Javidmehr
Tehran University of Medical Sciences
Outcome results
None listed