The Effect of Oral Powder Enriched with Curcumin and Probiotics on Patients with Metabolic Syndrome

Production of Functional Oral Powder Enriched with Curcumin, Probiotics, and their Combination and Determination of their Effect on Appetite, Leptin, and Ghrelin Hormones and Some Anthropometric Indices in Patients with Metabolic Syndrome with Overweight or Obesity: a Randomized Double-Blind Controlled Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220315054290N1

Enrollment

124

Registered

2022-04-03

Start date

2022-06-22

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic syndrome. Metabolic syndrome

Interventions

Intervention 1: The first intervention group will receive a daily oral powder enriched with 1 gram of curcumin for 8 weeks. Curcumin powder will be supplied by Karen Company. Intervention 2: The secon

Eligibility

Sex/Gender

All

Age

30 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age: 30-60 years old Metabolic syndrome patients are diagnosed based on the Adult Treatment Panel III (ATP III) criterion Consent to participate in the study

Exclusion criteria

Exclusion criteria: Pregnancy Lactation Suffering from kidney, liver, and systemic diseases at the beginning of the study Metabolic, endocrine, and cardiovascular diseases except diabetes, dyslipidemia, and hypertension Take any supplements or antibiotics during the previous 3 months

Design outcomes

Primary

Measure	Time frame
Leptin hormone. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Leptin kit (ELISA).;Ghrelin hormone. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Ghrelin kit (ELISA).;Appetite. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Visual Analog Scale (VAS) questionnaire.	—

Measure

Time frame

Leptin hormone. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Leptin kit (ELISA).;Ghrelin hormone. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Ghrelin kit (ELISA).;Appetite. Timepoint: Before the study and 8 weeks after the start of the study. Method of measurement: Visual Analog Scale (VAS) questionnaire.

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Secondary

Measure	Time frame
Weight. Timepoint: Before the intervention and 8 weeks after the start of the intervention. Method of measurement: Scale.;Waist circumference. Timepoint: Before the intervention and 8 weeks after the start of the intervention. Method of measurement: Inelastic tape.;Body fat percentage. Timepoint: Before the intervention and 8 weeks after the start of the intervention. Method of measurement: Body analyzer device.	—

Measure

Time frame

Weight. Timepoint: Before the intervention and 8 weeks after the start of the intervention. Method of measurement: Scale.;Waist circumference. Timepoint: Before the intervention and 8 weeks after the start of the intervention. Method of measurement: Inelastic tape.;Body fat percentage. Timepoint: Before the intervention and 8 weeks after the start of the intervention. Method of measurement: Body analyzer device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzaneh Mohammadi

Shiraz University of Medical Sciences

mohamadyfa@sums.ac.ir+98 71 3725 8099

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026