The Effect of Selenium Supplement on subclinical Hypothyroidism in children

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220314054284N1

Enrollment

148

Registered

2022-06-22

Start date

2022-04-21

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hypothyroidism. Subclinical iodine-deficiency hypothyroidism

Interventions

Intervention 1: Intervention group: Intervention group: In patients with subclinical hypothyroidism, levothyroxine treatment will be started after 3 to 6 months of follow-up. The treatment will be bas

Eligibility

Sex/Gender

All

Age

3 Years to 16 Years

Inclusion criteria

Inclusion criteria: Children with subclinical hypothyroidism Age 3- 16 years

Exclusion criteria

Exclusion criteria: Dissatisfaction with participating in the study Failure to follow the patient Lack of patient medication compliance by parents

Design outcomes

Primary

Measure	Time frame
The amount of changes in the level of primary variables (TSH). Timepoint: Sections for measuring thyroid hormone levels (TSH) before the intervention and 3 months after (as soon as the treatment period ends). Method of measurement: Comparison of the effect of selenium supplementation on the reduction of TSH level.;The amount of changes in the level of primary variables (selenium). Timepoint: Sections for measuring of selenium level before the intervention and 3 months after (as soon as the treatment period ends). Method of measurement: Comparison of the effect of selenium supplementation on selenium changes.;The amount of changes in the level of primary variables of FT4. Timepoint: Sections for measuring of FT4 level before the intervention and 3 months after (as soon as the treatment period ends). Method of measurement: Comparison of the effect of selenium supplementation on the reduction of T FT4 level.	—

Measure

Time frame

The amount of changes in the level of primary variables (TSH). Timepoint: Sections for measuring thyroid hormone levels (TSH) before the intervention and 3 months after (as soon as the treatment period ends). Method of measurement: Comparison of the effect of selenium supplementation on the reduction of TSH level.;The amount of changes in the level of primary variables (selenium). Timepoint: Sections for measuring of selenium level before the intervention and 3 months after (as soon as the treatment period ends). Method of measurement: Comparison of the effect of selenium supplementation on selenium changes.;The amount of changes in the level of primary variables of FT4. Timepoint: Sections for measuring of FT4 level before the intervention and 3 months after (as soon as the treatment period ends). Method of measurement: Comparison of the effect of selenium supplementation on the reduction of T FT4 level.

—

Secondary

Measure	Time frame
Changes in the body's metabolism. Timepoint: Before and 3 months after the start of the intervention. Method of measurement: Evaluation of weight, improvement of patient symptoms including constipation, fatigue, appetite, brittle nails and hair loss, etc.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hossein Zaeri

Gorgan University of Medical Sciences

dr.zaeri_endocrine@yahoo.com+98 17 3232 0661

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026