Skip to content

Comparison of the effects of conjugated estrogen with vaginal sildenafil on endometrial diameter

Comparison of the effects of conjugated estrogen with vaginal sildenafil on endometrial diameter of patients treated by intracytoplasmic sperm injection(ICSI) admitting to Urmia Shahid Motahari and Mahzad Hospital

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220314054278N1
Enrollment
30
Registered
2022-05-03
Start date
2022-03-16
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Influence of different factors on endometrial thickness.

Interventions

Intervention 1: Intervention group: Patients receiving Estradiol Valerate 2 mg(Brand name: Abu Reihan estradiol valerate, Abu Reihan pharmaceuticals) 2 tablets TDS plus vaginal sildenafil 50 mg(Brand

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1.Patients undergoing IVF who did not conceive according to the standard uterine preparation protocol 2.Having two frozen embryos or more

Exclusion criteria

Exclusion criteria: Hypertension(HTN) treated with nitrates Cerebrovascular accident(CVA) Thrombophilia Using drugs with nitrate derivatives

Design outcomes

Primary

MeasureTime frame
Endometrial Thickness. Timepoint: Day 14 of the menstrual cycle at the time of routine endometrial preparation protocol and after receiving vaginal sildenafil as TDS with 2 mg estradiol valerate as TDS. Method of measurement: Sonography.

Secondary

MeasureTime frame
Gravidity. Timepoint: At the beginning of study. Method of measurement: Oral question.;Chemical pregnancy rate. Timepoint: After performing the intervention on the study groups. Method of measurement: B-HCG serum level measurement.;Abortion. Timepoint: Clinical symptoms in favor of loss of pregnancy products. Method of measurement: Sonography and Clinical exam based.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarnaz Ettehdi

Oroumia University of Medical Sciences

farnazettehadi1989@yahoo.com+98 41 3331 5198

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026