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?The effect of contrast agent reduction and low dose radiation on image quality in Pulmonary CT angiography

Investigating the effect of contrast agent reduction and lowering radiation dose on the image quality of pulmonary Computed Tomography (CT) in patients suspected of pulmonary thromboembolism using iterative reconstruction

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220313054273N1
Enrollment
40
Registered
2022-08-19
Start date
2022-08-23
Completion date
Unknown
Last updated
2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary thromboembolism. Pulmonary embolism

Interventions

Intervention 1: Intervention group: Patients suspected of pulmonary embolism referred to Shahid Faghihi Hospital (Shiraz) will be scanned by contrast agent reduction and radiation dose reduction proto

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who are suspicious of pulmonary emboly on the basis of clinical indication Abnormal level of plasma D-dimer Having deep veins thrombosis of lower limb age > 18 years BMI less than 30kg/m2 GFR greater than 60ml/min/1.73m2 Creatinine less than 1.3mg/ml Willingness to participate in the study and sign informed consent Does not have allergy to iodine contrast

Exclusion criteria

Exclusion criteria: Patient with severe pneumonia and atelectasis Confirmed pregnancy or suspicious of pregnancy Critically ill patient or hospitalized in ICU

Design outcomes

Primary

MeasureTime frame
The objective image quality of pulmonary CT Angio will be determined by radiologists through a scoring system. The quantitative image quality will be determined by quantitative parameters such as Signal-to-Noise Ratio. The quantity of radiation dose to the patient will be measured by the CT system. The related values will be shown on the Dose Report Page available at the end of the image series. Timepoint: The CT images will be sent to Picture Archiving and Communication System immediately after the scanning procedure completed. Then the qualitative and quantitative evaluation of the image quality of pulmonary CT Angio will perform. The results of the dose measurement will be available immediately after completing the scan. Method of measurement: Quantitative pulmonary Computed Tomography Angio (CTA) image quality will be measured by Signal-to-Noise Ratio (SNR). SNR results from the division of the mean CT density of the main pulmonary arteries (left and right) filled with contrast agent by the standard deviation of the background region (without contrast agent for example muscles surrounding the scapula). Qualitative pulmonary CT angiography is measured by the scores which are devoted to each series of images. Qualitative pulmonary CT angiography image quality will be measured by visual assessment. In this method the radiologist will use a scoring system on the basis of 5 scale scores as follow, (1) undiagnosable pulmonary CTA image (2) limited diagnostic value (3) sufficient diagnostic value (4) good image quality (5) excellent diagnostic value. Radiation dose to the patient will be measured by CT dose indices which are available on the page of dose report at the end of the CT image series.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRezvan Ravanfar Haghighi

Shiraz University of Medical Sciences

sravanfarr@gmail.com+98 71 3628 1464

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026