Evaluation of Additive effect of sodium bicarbonate with early goal-directed therapy in management of patients with severe sepsis and septic shock

Evaluation of Additive effect of sodium bicarbonate with early goal-directed therapy in the first three hours of hemodynamic management of patients with severe sepsis and septic shock in intensive care units of Imam Reza hospital, Mashhad

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220310054246N1

Enrollment

Registered

2023-04-17

Start date

2023-05-22

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Severe sepsis and septic shock. Condition 2: Metabolic acidosis. Other shock Acidosis

Interventions

Intervention 1: Intervention group: Sodium bicarbonate solution with a concentration of 7.5% in the amount of half of the deficiency calculated by the method (weight*base base*0.3) will be added to th

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with severe sepsis Patients with septic shock Age between 18 and 80 years old

Exclusion criteria

Exclusion criteria: Dissatisfaction of patients Patients with incurable diffuse malignancy Patients with alkalotic gasometry Patients receiving sodium bicarbonate prior to study entry Patients with hypernatremia Patients receiving colloidal solutions Any type of limitation in the administration of volume and sodium bicarbonate

Design outcomes

Primary

Measure	Time frame
Investigating the possibility of increased stability of hemodynamic parameters such as blood pressure and heart rate. Timepoint: Before the intervention and three hours later. Method of measurement: Cardiac monitoring device.;Investigating the possibility of improving gasometric parameters such as acidity and sodium bicarbonate. Timepoint: Before the intervention and three hours later. Method of measurement: Performing gasometry of arterial blood samples in a laboratory manner.	—

Measure

Time frame

Investigating the possibility of increased stability of hemodynamic parameters such as blood pressure and heart rate. Timepoint: Before the intervention and three hours later. Method of measurement: Cardiac monitoring device.;Investigating the possibility of improving gasometric parameters such as acidity and sodium bicarbonate. Timepoint: Before the intervention and three hours later. Method of measurement: Performing gasometry of arterial blood samples in a laboratory manner.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Noori

Mashhad University of Medical Sciences

nourie981@mums.ac.ir+98 51 3854 3031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026