Paraquat herbicide poisoning.
Conditions
Interventions
Intervention 1: Intervention group: They will receive thalidomide tablets at a dose of 200 mg twice a day (morning and night) for 5 days. Intervention 2: Control group: Common treatments.
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Definitive use of paraquat herbicide with toxic dose (based on history, clinical examination, endoscopic findings) Patients' satisfaction to participate in the study
Exclusion criteria
Exclusion criteria: Poisoning with other herbicides other than Paraquat (based on history, clinical examination, endoscopic findings) Non-toxic dose of paraquat (endoscopy and normal tests) Lack of cooperation of patients to take medicine due to oral ulcers Patient dissatisfaction to participate in the study Existence of underlying lung diseases Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of malondialdehyde. Timepoint: After the intervention. Method of measurement: Spectrophotometry.;Measurement of glutathione content. Timepoint: After the intervention. Method of measurement: Spectrophotometry.;Intravenous blood gas levels. Timepoint: After the intervention. Method of measurement: Laboratory experiment.;Percentage of arterial oxygen saturation. Timepoint: After the intervention. Method of measurement: Laboratory experiment.;Mortality rate. Timepoint: After the intervention. Method of measurement: Mortality rate. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShakiba Farhadpour
Kerman University of Medical Sciences
Outcome results
None listed